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miRTarBase - #MIRT023295 -
pre-miRNA Information
pre-miRNA hsa-mir-122   
Genomic Coordinates chr18: 58451074 - 58451158
Synonyms MIR122A, MIRN122, MIRN122A, hsa-mir-122, miRNA122, miRNA122A, MIR122
Description Homo sapiens miR-122 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-122-5p
Sequence 15| UGGAGUGUGACAAUGGUGUUUG |36
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 18 + 58451091 29233923 MiREDiBase
C-to-U 11 18 + 58451098 28550310 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1258166649 1 dbSNP
rs1426570658 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles

Circulating MicroRNA Expression Profiling
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MYCBP   
Synonyms AMY-1
Description MYC binding protein
Transcript NM_012333   
Expression
Putative miRNA Targets on MYCBP
3'UTR of MYCBP
(miRNA target sites are highlighted)		 
>MYCBP|NM_012333|3'UTR
   1 GATTCTTCTCAGTTTGAAAGACAATGAAAAATGGTTTTGTATGACTTGAATAGTTTGTATAGTATATAATCTTTTCTGAA
  81 CAGATGCTATAGAACTCTTTTAATATGTTTAATTCACCTATCACACTCTGTTAAAAACACATAGAATCATCAATAAAAAC
 161 TCAATATAACTTTCTTTGGGTCTTAAAGCAGGAGAATCCAAAGTAAATCCTGAACAAAACCTAAACACAGCCATCTAACT
 241 CATTACCTTAAAAGACATTCTGTTTATTAGTCTGATTAGGAATGATGGCACTGGTTGTATTTTAGCCAAGACAGTTTAGC
 321 ATGGAGCTATTCCTTGGTGCAGTTCAGGATATGAACACAGGTACAGTCATTCTTTGAAGGTGACACTGTTCTGTATATTC
 401 CCTATAGGCAGCTGGAGAGATCTGTGTGACACAAGATGCTTTTGTACGGGTTCCCATGAATCTTCTGCTCTTGTTTGTGT
 481 GACATGGAACAAATAACTTCTTTGCCACCACTTTGCCTTAGATAACTGTGTGTGTGTGTGCCAGTTTGAACTCTGACACC
 561 ACATTTTCCTTCTATGCAATCATGCCTGTCTGATAATCTTGCATTGCTTTCCTCTGAGCTTTAGTGGGTCCTAGTTGCAC
 641 ACTGGCCTTTCTGTGCTGTTTTTCAATTTGCCTAATAATAGCAGTTACCCTGATTGTAATTTATGTAACTTTAAACAGGA
 721 TCACACTGTACCCCCTGCCTGCCTTATTTGCTTACTGAGCACAGGACAGAGGCAATATACAACTCTGGGTTCACACACAA
 801 GCTGAGATGAGAAGAGGAATGAGCCATATATTGGGGAAAATCATAGTTTGTAGGTATAATTATATAGTGCTTTTCTCCCT
 881 CAAAGTATTTTTCTAGCCTTGAATTCATTTTATCTTCATTATCCCTGTGAAGTAGGTGGGACAAGTATAAGGGGAAGAGG
 961 GGTGCTGAATTTTTAGGCCAAAGACTGATATTAATACAAATCACTCACTAACTGTAGAGCCTTGGGCATTATCAGTGAAC
1041 TACTCTGAGATTTACTGTCTTCATCTGTTTAATGAGTAGAATGTCCGTGATGCCTACCTCACAGGGTTGTTGTGAGGGTC
1121 AAATGAGAATGTATGTGAAAGATTTGTAAATGGTAAAGCACTATATTCTTGTTTGTTAGTCCTTTTTCCTTTCTTTGGGT
1201 AGACCTACAGTCAGATGTTTTGTTTTATGGATCACTTATTTTCCTTACTGGTAGACTGTCGTTTTATAGACATATTCCTA
1281 TTTCATATATTCTCTCCCTGTTGTTAGAGAACCTATCTTTGTTTTTGGTCAAAACACACATAGAAAACAAAATGATCCAA
1361 TGAAAACTGGTTTAACTAGCAAAAGCCTTGGCACCTGTTGGAGACTATGACCAAGCCAATAAAAAGGGCATTTAAATCAG
1441 CCCTGTTAGTAGGAATGTGGCTATGGCTGGTGCCTCTTCTAGTCACAAGTTTGTTTTTGGAGGGGGTCCAGAAGATCATT
1521 CCCTTGCATAGATTTCTCTTTTACCAATTTGAGTGCCTCCTACATGGGCAGCAGTGGACTAAGTGCTGGGTGTGATAAAG
1601 AGGAATGACTTAATTATGAGACTGTATATAATCAAATACAGTGTGGGTTAGGACCTGTGGCAGACCATTATAATAAAGCA
1681 TGGCCCCGTGAGGGTTTTGAAAGAGAGAGAGACTTGGCTTCCTTAGTTGGTATGATAGTTTCTTGGTAGATACAGGTTGA
1761 AAATTTTTTGTGGCAGCCAATCCTCATGGGCTTTTTACTCATTTGATTAGTATTAATATTTATGTCAGTAAGCCAGGTGA
1841 CTGTGACTGTCTTTGGTACCATCCTTTTTGAACAGAAAGGCAACATGTGGGTTGGATAATCACACTTTTAGGTGAAACTG
1921 ACTTGCTTAAACTGTAACAGTCAGTGCTATTTAAGAATTCAGGATAAGCTTAGCCTCTAGAGGTCCTCTTCAACATTTCT
2001 GTCAAGGATTTGGATGAATACAACAAGATGCTCCATGGAAGAGAAAATGGATAAATGGATCCCACCAGTTAAGCTCCTAT
2081 TATGCTTCAGCTGCTTTGTCTATAAAATATCGACTTCACATCTTGCCTATCTCACAAGTTGGTTGTAAGAATCAAATTAA
2161 ATATAATGGATGTAAAAGTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1 
miRNA  3' guuuGUGGUAACAGUGUGAGGu 5'
              ||||  | ||||||||: 
Target 5' aattCACC--TATCACACTCTg 3'
 		111 - 130 146.00 -16.50
2 
miRNA  3' guUUGUGGUAACA-GUGUGAGGu 5'
            :||||::|| | :|:|:||| 
Target 5' gtGACACTGTTCTGTATATTCCc 3'
 		380 - 402 136.00 -13.90
3 
miRNA  3' guuuguGGUAACAGUGUGAGGu 5'
                ::|| | ||:|:||| 
Target 5' gtcgttTTATAGACATATTCCt 3'
 		1258 - 1279 124.00 -9.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31529906 67 COSMIC
COSN31587681 92 COSMIC
COSN31580662 174 COSMIC
COSN31521055 254 COSMIC
COSN6035397 385 COSMIC
COSN10048268 457 COSMIC
COSN31552359 490 COSMIC
COSN28737461 642 COSMIC
COSN31542787 707 COSMIC
COSN28201012 772 COSMIC
COSN7219218 821 COSMIC
COSN20921664 881 COSMIC
COSN26482157 923 COSMIC
COSN21373218 1026 COSMIC
COSN17076344 1127 COSMIC
COSN31516873 1141 COSMIC
COSN31608990 1149 COSMIC
COSN393002 1261 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1371569024 7 dbSNP
rs1240207792 10 dbSNP
rs371950267 11 dbSNP
rs74064928 12 dbSNP
rs1405930413 16 dbSNP
rs1279422519 17 dbSNP
rs370144310 24 dbSNP
rs867141748 28 dbSNP
rs759735395 41 dbSNP
rs1348429179 43 dbSNP
rs1285268943 47 dbSNP
rs1381292401 48 dbSNP
rs774454245 48 dbSNP
rs1292929437 51 dbSNP
rs1378862301 53 dbSNP
rs755019611 55 dbSNP
rs1227455939 57 dbSNP
rs751688623 59 dbSNP
rs190835595 60 dbSNP
rs763241718 68 dbSNP
rs763971404 71 dbSNP
rs1485387583 72 dbSNP
rs772034435 75 dbSNP
rs1220298141 76 dbSNP
rs759459510 78 dbSNP
rs775532643 81 dbSNP
rs562661368 88 dbSNP
rs542358072 89 dbSNP
rs1428734026 90 dbSNP
rs1046393380 98 dbSNP
rs950032770 100 dbSNP
rs1407493851 103 dbSNP
rs1453415350 105 dbSNP
rs1287506255 106 dbSNP
rs186336863 116 dbSNP
rs917159182 122 dbSNP
rs1177933495 130 dbSNP
rs991375743 138 dbSNP
rs559732045 140 dbSNP
rs539876533 144 dbSNP
rs1455333716 145 dbSNP
rs1282085091 150 dbSNP
rs1410714228 155 dbSNP
rs746008341 155 dbSNP
rs1224832603 164 dbSNP
rs937176996 165 dbSNP
rs1316303819 166 dbSNP
rs909675842 170 dbSNP
rs753040593 174 dbSNP
rs34964567 181 dbSNP
rs1262321066 189 dbSNP
rs984285364 192 dbSNP
rs951154983 208 dbSNP
rs1268259743 210 dbSNP
rs1234947709 220 dbSNP
rs1311408920 228 dbSNP
rs181447232 243 dbSNP
rs1430546537 253 dbSNP
rs1025768525 262 dbSNP
rs1157331957 266 dbSNP
rs149529572 269 dbSNP
rs749120856 275 dbSNP
rs1453984253 277 dbSNP
rs1302078448 292 dbSNP
rs1363333626 300 dbSNP
rs1256979617 305 dbSNP
rs965627592 306 dbSNP
rs1205599022 307 dbSNP
rs778106551 309 dbSNP
rs1018493457 317 dbSNP
rs1267682543 320 dbSNP
rs1007059349 323 dbSNP
rs2104423 330 dbSNP
rs545675392 342 dbSNP
rs893985845 349 dbSNP
rs1282185658 360 dbSNP
rs1032466918 361 dbSNP
rs1489930890 369 dbSNP
rs1224785143 370 dbSNP
rs1247404064 371 dbSNP
rs1480587254 372 dbSNP
rs1244041622 375 dbSNP
rs1000060196 384 dbSNP
rs1410818239 391 dbSNP
rs1440628665 401 dbSNP
rs902578383 404 dbSNP
rs1382954871 412 dbSNP
rs1046860656 416 dbSNP
rs1432175529 419 dbSNP
rs949427350 424 dbSNP
rs1163633341 431 dbSNP
rs895125859 433 dbSNP
rs1055721524 435 dbSNP
rs1402080413 439 dbSNP
rs770187366 440 dbSNP
rs377695740 447 dbSNP
rs1312707113 448 dbSNP
rs138090723 455 dbSNP
rs1248522855 457 dbSNP
rs983968380 461 dbSNP
rs929736137 465 dbSNP
rs780772466 470 dbSNP
rs758146111 473 dbSNP
rs1458623551 482 dbSNP
rs77133306 485 dbSNP
rs1050463 487 dbSNP
rs1017862535 495 dbSNP
rs1163540326 497 dbSNP
rs1418373274 507 dbSNP
rs1407651835 510 dbSNP
rs1216829688 517 dbSNP
rs985712145 528 dbSNP
rs1448937760 538 dbSNP
rs1334439345 539 dbSNP
rs1032949335 541 dbSNP
rs1384793545 541 dbSNP
rs958282524 541 dbSNP
rs1361565944 544 dbSNP
rs1287490761 546 dbSNP
rs1208972522 555 dbSNP
rs1319173490 558 dbSNP
rs1203662290 562 dbSNP
rs531600446 574 dbSNP
rs1261647097 576 dbSNP
rs1462891972 578 dbSNP
rs999686157 583 dbSNP
rs902651727 585 dbSNP
rs1226063482 587 dbSNP
rs1187730237 588 dbSNP
rs1423796060 588 dbSNP
rs1480060337 591 dbSNP
rs1174106203 603 dbSNP
rs1363911361 605 dbSNP
rs1025076126 614 dbSNP
rs1317402950 619 dbSNP
rs113341727 623 dbSNP
rs1347714727 633 dbSNP
rs1321993619 636 dbSNP
rs11538784 642 dbSNP
rs1271997191 663 dbSNP
rs1341272765 664 dbSNP
rs773119130 666 dbSNP
rs1281860390 682 dbSNP
rs1326323840 690 dbSNP
rs758720326 694 dbSNP
rs1166094783 705 dbSNP
rs1444914439 716 dbSNP
rs1217564827 724 dbSNP
rs11538785 731 dbSNP
rs1263468444 733 dbSNP
rs1001491394 734 dbSNP
rs1389687286 736 dbSNP
rs1431285028 737 dbSNP
rs888344602 738 dbSNP
rs1157750155 753 dbSNP
rs1405603356 755 dbSNP
rs1158220061 761 dbSNP
rs534213879 764 dbSNP
rs1048730974 765 dbSNP
rs1300212821 775 dbSNP
rs929837474 778 dbSNP
rs1404370599 780 dbSNP
rs571614002 792 dbSNP
rs1476528705 799 dbSNP
rs1301402239 812 dbSNP
rs1333316154 813 dbSNP
rs1245129746 816 dbSNP
rs1197917701 820 dbSNP
rs1279320054 825 dbSNP
rs1348910899 835 dbSNP
rs184729417 837 dbSNP
rs1490468138 838 dbSNP
rs181253603 840 dbSNP
rs1225834066 841 dbSNP
rs538095589 842 dbSNP
rs1219593531 843 dbSNP
rs1202983593 849 dbSNP
rs1270460996 852 dbSNP
rs373748499 853 dbSNP
rs1452105457 865 dbSNP
rs1181069298 871 dbSNP
rs918390767 875 dbSNP
rs1040809183 881 dbSNP
rs1159062971 889 dbSNP
rs943784529 893 dbSNP
rs1424323000 905 dbSNP
rs910929568 922 dbSNP
rs1393039957 924 dbSNP
rs985076491 927 dbSNP
rs1365070416 930 dbSNP
rs1273942175 947 dbSNP
rs958311562 952 dbSNP
rs1334540997 953 dbSNP
rs925572247 961 dbSNP
rs750828994 962 dbSNP
rs966906851 968 dbSNP
rs978726557 968 dbSNP
rs1293305595 970 dbSNP
rs1346586362 973 dbSNP
rs1305320749 985 dbSNP
rs1194742198 990 dbSNP
rs1025529341 991 dbSNP
rs1370438446 997 dbSNP
rs1171224207 999 dbSNP
rs1179003354 1002 dbSNP
rs1050468 1007 dbSNP
rs568976811 1014 dbSNP
rs1444217631 1016 dbSNP
rs1181912812 1024 dbSNP
rs1423134468 1026 dbSNP
rs1172279146 1031 dbSNP
rs1370419421 1033 dbSNP
rs959440826 1040 dbSNP
rs1131158 1045 dbSNP
rs753950980 1045 dbSNP
rs1033704408 1049 dbSNP
rs1270843856 1065 dbSNP
rs1394938982 1081 dbSNP
rs1006211049 1086 dbSNP
rs1179687796 1087 dbSNP
rs1332452836 1114 dbSNP
rs1382579493 1118 dbSNP
rs887744987 1133 dbSNP
rs1314352799 1135 dbSNP
rs1233328989 1152 dbSNP
rs1206518794 1153 dbSNP
rs1226000741 1158 dbSNP
rs760303537 1159 dbSNP
rs878877117 1160 dbSNP
rs1277252926 1163 dbSNP
rs1048323867 1164 dbSNP
rs1459757736 1168 dbSNP
rs994450674 1168 dbSNP
rs549125026 1174 dbSNP
rs1424663356 1183 dbSNP
rs1192521074 1189 dbSNP
rs897021472 1193 dbSNP
rs1479081333 1201 dbSNP
rs1040855933 1208 dbSNP
rs1406000953 1209 dbSNP
rs1468530196 1227 dbSNP
rs1304988302 1231 dbSNP
rs768033122 1247 dbSNP
rs1402448039 1249 dbSNP
rs143986736 1260 dbSNP
rs189947460 1260 dbSNP
rs910960780 1261 dbSNP
rs1285614371 1263 dbSNP
rs1408322118 1266 dbSNP
rs1049440741 1268 dbSNP
rs1350430571 1282 dbSNP
rs1282511785 1287 dbSNP
rs936360353 1296 dbSNP
rs924901764 1298 dbSNP
rs140292765 1299 dbSNP
rs1357542500 1300 dbSNP
rs978376358 1314 dbSNP
rs546223231 1315 dbSNP
rs1333568752 1325 dbSNP
rs57043642 1327 dbSNP
rs147836506 1341 dbSNP
rs1489274344 1346 dbSNP
rs1194517874 1352 dbSNP
rs546284217 1358 dbSNP
rs918131259 1360 dbSNP
rs992309209 1362 dbSNP
rs1178654124 1365 dbSNP
rs1156700880 1373 dbSNP
rs1472174832 1376 dbSNP
rs959470255 1393 dbSNP
rs1178917832 1397 dbSNP
rs1374146541 1412 dbSNP
rs561964029 1419 dbSNP
rs1236405260 1430 dbSNP
rs1400024681 1432 dbSNP
rs1302038448 1439 dbSNP
rs1203699044 1447 dbSNP
rs1462383277 1450 dbSNP
rs376065376 1453 dbSNP
rs1301703384 1455 dbSNP
rs532804178 1462 dbSNP
rs1033774956 1463 dbSNP
rs1006284837 1464 dbSNP
rs1356153511 1467 dbSNP
rs1026121403 1471 dbSNP
rs1217409111 1479 dbSNP
rs1268325457 1481 dbSNP
rs1227388422 1482 dbSNP
rs761601932 1488 dbSNP
rs1316768626 1506 dbSNP
rs1418819668 1507 dbSNP
rs184250335 1507 dbSNP
rs41307836 1509 dbSNP
rs1381754010 1519 dbSNP
rs1419971101 1529 dbSNP
rs1162370837 1541 dbSNP
rs1363231884 1543 dbSNP
rs1438003350 1556 dbSNP
rs1293972590 1561 dbSNP
rs994139858 1564 dbSNP
rs759102632 1565 dbSNP
rs1311247913 1571 dbSNP
rs1379361229 1575 dbSNP
rs1241237761 1578 dbSNP
rs868321673 1583 dbSNP
rs1291121906 1589 dbSNP
rs1319946877 1600 dbSNP
rs576648999 1616 dbSNP
rs1377559921 1626 dbSNP
rs774385540 1628 dbSNP
rs1223902371 1633 dbSNP
rs897047745 1634 dbSNP
rs77450161 1638 dbSNP
rs543281688 1646 dbSNP
rs1177123421 1660 dbSNP
rs1008029467 1668 dbSNP
rs574893262 1671 dbSNP
rs879302446 1678 dbSNP
rs1439907154 1679 dbSNP
rs1182536851 1680 dbSNP
rs1453392357 1683 dbSNP
rs889593827 1687 dbSNP
rs1318862534 1688 dbSNP
rs1353837378 1699 dbSNP
rs1049471999 1713 dbSNP
rs1333117253 1713 dbSNP
rs1377445500 1718 dbSNP
rs41307838 1723 dbSNP
rs1314576617 1725 dbSNP
rs1377270168 1730 dbSNP
rs1160954769 1733 dbSNP
rs1313578530 1739 dbSNP
rs1215389602 1749 dbSNP
rs554356638 1751 dbSNP
rs1422015801 1753 dbSNP
rs117647542 1756 dbSNP
rs1353806204 1763 dbSNP
rs1458443392 1767 dbSNP
rs1203466967 1780 dbSNP
rs1183687214 1784 dbSNP
rs945671856 1786 dbSNP
rs1473603734 1788 dbSNP
rs1445995406 1803 dbSNP
rs1245664327 1804 dbSNP
rs1207761133 1808 dbSNP
rs1172664733 1816 dbSNP
rs773195112 1818 dbSNP
rs1485979537 1822 dbSNP
rs746605031 1823 dbSNP
rs1334496001 1824 dbSNP
rs938176623 1830 dbSNP
rs1450536233 1833 dbSNP
rs1218338339 1835 dbSNP
rs775108021 1841 dbSNP
rs1303497693 1843 dbSNP
rs1320448188 1846 dbSNP
rs879891543 1847 dbSNP
rs1280594606 1863 dbSNP
rs1319252908 1900 dbSNP
rs540843671 1901 dbSNP
rs1277007864 1905 dbSNP
rs1443772422 1908 dbSNP
rs1210465421 1910 dbSNP
rs1241157859 1928 dbSNP
rs984880487 1933 dbSNP
rs952226617 1958 dbSNP
rs781489512 1960 dbSNP
rs1295464367 1962 dbSNP
rs577960250 1967 dbSNP
rs972463418 1968 dbSNP
rs1362869046 1970 dbSNP
rs768567618 1971 dbSNP
rs1427088055 1975 dbSNP
rs776216173 1976 dbSNP
rs966045455 1982 dbSNP
rs1335033660 1987 dbSNP
rs1456149000 1995 dbSNP
rs1398183635 1998 dbSNP
rs191481765 2014 dbSNP
rs1341655612 2015 dbSNP
rs1164211950 2024 dbSNP
rs1273436107 2026 dbSNP
rs1008062305 2027 dbSNP
rs889626498 2046 dbSNP
rs1283054295 2048 dbSNP
rs1351110108 2057 dbSNP
rs747142598 2061 dbSNP
rs1263348924 2063 dbSNP
rs1490165485 2064 dbSNP
rs1196578281 2065 dbSNP
rs537763259 2066 dbSNP
rs1248398325 2073 dbSNP
rs1000657994 2075 dbSNP
rs1157814423 2079 dbSNP
rs903579771 2080 dbSNP
rs1418152910 2081 dbSNP
rs1428781127 2083 dbSNP
rs569166147 2085 dbSNP
rs780507329 2086 dbSNP
rs1361323477 2098 dbSNP
rs749872112 2099 dbSNP
rs1404842215 2100 dbSNP
rs1322080585 2105 dbSNP
rs542189559 2111 dbSNP
rs572235713 2121 dbSNP
rs750773886 2122 dbSNP
rs1374187401 2123 dbSNP
rs945047380 2131 dbSNP
rs34393348 2139 dbSNP
rs1358035693 2143 dbSNP
rs1056733320 2145 dbSNP
rs1452149351 2148 dbSNP
rs546300238 2154 dbSNP
rs771907135 2156 dbSNP
rs1984482 2178 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Grimson A; Farh KK; Johnston WK; et al.
- Molecular cell, 2007
Mammalian microRNAs (miRNAs) pair to 3'UTRs of mRNAs to direct their posttranscriptional repression. Important for target recognition are approximately 7 nt sites that match the seed region of the miRNA. However, these seed matches are not always sufficient for repression, indicating that other characteristics help specify targeting. By combining computational and experimental approaches, we uncovered five general features of site context that boost site efficacy: AU-rich nucleotide composition near the site, proximity to sites for coexpressed miRNAs (which leads to cooperative action), proximity to residues pairing to miRNA nucleotides 13-16, positioning within the 3'UTR at least 15 nt from the stop codon, and positioning away from the center of long UTRs. A model combining these context determinants quantitatively predicts site performance both for exogenously added miRNAs and for endogenous miRNA-message interactions. Because it predicts site efficacy without recourse to evolutionary conservation, the model also identifies effective nonconserved sites and siRNA off-targets.
LinkOut: [PMID: 17612493]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
IDDuplex structurePosition
1 
miRNA  3' guuugugguaacaGUGUGAGGu 5'
                       ::|||||| 
Target 5' -----------acUGCACUCCa 3'
 		1 - 11
2 
miRNA  3' guUUGUGGUAACAGUGUGAGGu 5'
            ::|: ||  |  | ||||| 
Target 5' cuGGCGACAGAGCGAGACUCCa 3'
 		14 - 35
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000397572.2 | 3UTR | ACUGCACUCCAGCCUGGCGACAGAGCGAGACUCCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.75 1.6e-3 0.692 4.4e-3 13 Click to see details
GSE14794 Lymphoblastoid cells -0.216 2.0e-2 -0.163 6.2e-2 90 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.286 1.1e-1 0.036 4.4e-1 20 Click to see details
GSE19350 CNS germ cell tumors -0.359 1.3e-1 -0.343 1.4e-1 12 Click to see details
GSE21849 B cell lymphoma -0.195 1.6e-1 0.022 4.5e-1 29 Click to see details
GSE26953 Aortic valvular endothelial cells 0.215 1.6e-1 0.187 1.9e-1 24 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.474 1.7e-1 0.543 1.3e-1 6 Click to see details
GSE28544 Breast cancer 0.183 2.0e-1 0.129 2.7e-1 24 Click to see details
GSE17498 Multiple myeloma 0.116 2.4e-1 0.046 3.9e-1 40 Click to see details
GSE32688 Pancreatic cancer -0.117 2.6e-1 -0.038 4.2e-1 32 Click to see details
GSE27834 Pluripotent stem cells 0.165 2.7e-1 0.029 4.6e-1 16 Click to see details
GSE42095 Differentiated embryonic stem cells 0.132 2.7e-1 -0.280 9.8e-2 23 Click to see details
GSE21687 Ependynoma primary tumors 0.057 3.3e-1 0.067 3.0e-1 64 Click to see details
GSE38226 Liver fibrosis -0.099 3.3e-1 0.011 4.8e-1 21 Click to see details
GSE17306 Multiple myeloma 0.028 4.2e-1 0.080 2.9e-1 49 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.026 4.5e-1 -0.044 4.2e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.002 5.0e-1 0.031 4.4e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.998 0.02 -0.500 0.33 3 Click to see details
STAD 0.696 0.03 0.619 0.05 8 Click to see details
KIRC -0.194 0.16 -0.216 0.13 29 Click to see details
LIHC 0.136 0.18 -0.067 0.32 49 Click to see details
KIRP 0.288 0.23 0.200 0.3 9 Click to see details
CHOL -0.197 0.31 -0.183 0.32 9 Click to see details
THCA 0.273 0.33 0.000 0.5 5 Click to see details
KICH 0.02 0.48 -0.119 0.39 8 Click to see details
ESCA 0.028 0.48 0.100 0.44 5 Click to see details
ESCA 0.028 0.48 0.100 0.44 5 Click to see details
ESCA 0.028 0.48 0.100 0.44 5 Click to see details
ESCA 0.028 0.48 0.100 0.44 5 Click to see details
ESCA 0.028 0.48 0.100 0.44 5 Click to see details
ESCA 0.028 0.48 0.100 0.44 5 Click to see details
MiRNA Regulatory Network:
Functional analysis:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR) Other evidence
Transcription factor regulation Circular RNA sponge
539 hsa-miR-122-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000012 CYP7A1 cytochrome P450 family 7 subfamily A member 1 3 1
MIRT000364 IGF1R insulin like growth factor 1 receptor 4 3
MIRT000365 SRF serum response factor 4 1
MIRT000663 RAC1 Rac family small GTPase 1 5 2
MIRT000717 RHOA ras homolog family member A 2 2
MIRT003006 CCNG1 cyclin G1 4 4
MIRT003079 GTF2B general transcription factor IIB 2 1
MIRT003080 GYS1 glycogen synthase 1 4 2
MIRT003081 ANK2 ankyrin 2 3 1
MIRT003082 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 3 1
MIRT003083 ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 4 2
MIRT003084 ANXA11 annexin A11 4 2
MIRT003085 ALDOA aldolase, fructose-bisphosphate A 3 2
MIRT003086 RAB6B RAB6B, member RAS oncogene family 3 1
MIRT003087 RAB11FIP1 RAB11 family interacting protein 1 5 3
MIRT003088 FOXP1 forkhead box P1 3 1
MIRT003089 MECP2 methyl-CpG binding protein 2 3 2
MIRT003090 NCAM1 neural cell adhesion molecule 1 4 3
MIRT003091 UBAP2 ubiquitin associated protein 2 3 1
MIRT003092 TBX19 T-box 19 3 1
MIRT003093 AACS acetoacetyl-CoA synthetase 3 1
MIRT003094 DUSP2 dual specificity phosphatase 2 3 1
MIRT003095 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 3 1
MIRT003097 MAPK11 mitogen-activated protein kinase 11 3 1
MIRT003098 FUNDC2 FUN14 domain containing 2 3 1
MIRT003099 AKT3 AKT serine/threonine kinase 3 3 3
MIRT003100 TPD52L2 tumor protein D52 like 2 4 3
MIRT003102 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 4 2
MIRT003103 G6PC3 glucose-6-phosphatase catalytic subunit 3 4 2
MIRT003104 AP3M2 adaptor related protein complex 3 mu 2 subunit 3 1
MIRT003105 SLC7A1 solute carrier family 7 member 1 4 4
MIRT003106 XPO6 exportin 6 3 1
MIRT003107 FOXJ3 forkhead box J3 3 1
MIRT003108 SLC7A11 solute carrier family 7 member 11 3 1
MIRT003109 TRIB1 tribbles pseudokinase 1 3 1
MIRT003110 EGLN3 egl-9 family hypoxia inducible factor 3 3 1
MIRT003111 NUMBL NUMB like, endocytic adaptor protein 3 1
MIRT003112 ADAM17 ADAM metallopeptidase domain 17 3 5
MIRT003727 DSTYK dual serine/threonine and tyrosine protein kinase 3 2
MIRT003728 FAM117B family with sequence similarity 117 member B 3 1
MIRT004364 BCL2L2 BCL2 like 2 4 2
MIRT004527 PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 2 1
MIRT004879 ADAM10 ADAM metallopeptidase domain 10 5 1
MIRT005782 ACVR1C activin A receptor type 1C 1 1
MIRT006123 PRKRA protein activator of interferon induced protein kinase EIF2AK2 4 1
MIRT006421 WNT1 Wnt family member 1 3 1
MIRT007007 PTPN1 protein tyrosine phosphatase, non-receptor type 1 1 1
MIRT007081 NT5C3A 5'-nucleotidase, cytosolic IIIA 1 1
MIRT007082 P4HA1 prolyl 4-hydroxylase subunit alpha 1 1 1
MIRT007083 ZNF395 zinc finger protein 395 1 1
MIRT007084 SOCS1 suppressor of cytokine signaling 1 1 1
MIRT023217 SSR3 signal sequence receptor subunit 3 1 1
MIRT023218 PHOX2A paired like homeobox 2a 1 1
MIRT023219 DZIP1L DAZ interacting zinc finger protein 1 like 1 1
MIRT023220 GSTM2 glutathione S-transferase mu 2 1 1
MIRT023221 RAI14 retinoic acid induced 14 1 1
MIRT023222 STARD13 StAR related lipid transfer domain containing 13 1 1
MIRT023223 CNN3 calponin 3 1 1
MIRT023224 A2M alpha-2-macroglobulin 1 1
MIRT023225 EFCAB6 EF-hand calcium binding domain 6 1 1
MIRT023226 GLOD4 glyoxalase domain containing 4 1 1
MIRT023227 CALR calreticulin 1 1
MIRT023228 POFUT1 protein O-fucosyltransferase 1 1 1
MIRT023229 PYGO1 pygopus family PHD finger 1 1 1
MIRT023230 CDY2B chromodomain Y-linked 2B 1 1
MIRT023231 CDC42EP3 CDC42 effector protein 3 1 1
MIRT023232 CS citrate synthase 3 3
MIRT023233 RNF170 ring finger protein 170 3 3
MIRT023234 GTF3C6 general transcription factor IIIC subunit 6 1 1
MIRT023235 ZNF321P zinc finger protein 321, pseudogene 1 1
MIRT023236 LAMP1 lysosomal associated membrane protein 1 1 1
MIRT023237 SLC52A2 solute carrier family 52 member 2 1 1
MIRT023238 ZNF658 zinc finger protein 658 1 1
MIRT023239 ATP13A3 ATPase 13A3 1 1
MIRT023240 CPNE5 copine 5 1 1
MIRT023241 KATNAL1 katanin catalytic subunit A1 like 1 1 1
MIRT023242 TMEM136 transmembrane protein 136 1 1
MIRT023243 ATP11A ATPase phospholipid transporting 11A 1 1
MIRT023244 TMEM74 transmembrane protein 74 1 1
MIRT023245 ANKRD10 ankyrin repeat domain 10 1 1
MIRT023246 TBL1XR1 transducin beta like 1 X-linked receptor 1 1 1
MIRT023247 USP10 ubiquitin specific peptidase 10 1 1
MIRT023248 AKAP11 A-kinase anchoring protein 11 1 1
MIRT023249 BACH2 BTB domain and CNC homolog 2 1 1
MIRT023250 HCCS holocytochrome c synthase 1 1
MIRT023251 Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 1 1
MIRT023252 GTDC2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 1 1
MIRT023253 CTPS1 CTP synthase 1 1 1
MIRT023254 SLC44A1 solute carrier family 44 member 1 1 1
MIRT023255 CLSPN claspin 1 1
MIRT023256 RABGEF1 RAB guanine nucleotide exchange factor 1 1 1
MIRT023257 FBXO7 F-box protein 7 1 1
MIRT023258 NCDN neurochondrin 1 1
MIRT023259 SOX2 SRY-box 2 1 1
MIRT023260 ZNF618 zinc finger protein 618 1 1
MIRT023261 ABLIM1 actin binding LIM protein 1 1 1
MIRT023262 ZBTB4 zinc finger and BTB domain containing 4 1 1
MIRT023263 LUZP1 leucine zipper protein 1 1 1
MIRT023264 NLGN3 neuroligin 3 1 1
MIRT023265 PRR11 proline rich 11 1 1
MIRT023266 HHAT hedgehog acyltransferase 1 1
MIRT023267 UBE2L3 ubiquitin conjugating enzyme E2 L3 1 1
MIRT023268 DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 1 1
MIRT023269 FAM102A family with sequence similarity 102 member A 1 1
MIRT023270 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT023271 DENND2C DENN domain containing 2C 1 1
MIRT023272 HMOX1 heme oxygenase 1 3 2
MIRT023273 USP28 ubiquitin specific peptidase 28 1 1
MIRT023274 KRT18 keratin 18 1 1
MIRT023275 BPGM bisphosphoglycerate mutase 1 1
MIRT023276 ZNF233 zinc finger protein 233 1 1
MIRT023277 SLC25A30 solute carrier family 25 member 30 1 1
MIRT023278 ANKRD9 ankyrin repeat domain 9 3 3
MIRT023279 RLN1 relaxin 1 1 1
MIRT023280 DDIT3 DNA damage inducible transcript 3 1 1
MIRT023281 TRIM65 tripartite motif containing 65 1 1
MIRT023282 B4GALT1 beta-1,4-galactosyltransferase 1 1 1
MIRT023283 ANXA7 annexin A7 1 1
MIRT023284 SLC19A2 solute carrier family 19 member 2 1 1
MIRT023285 MARCKS myristoylated alanine rich protein kinase C substrate 1 1
MIRT023286 CLEC11A C-type lectin domain containing 11A 1 1
MIRT023287 CENPF centromere protein F 1 1
MIRT023288 CLDN18 claudin 18 1 1
MIRT023289 PFDN1 prefoldin subunit 1 1 1
MIRT023290 SPAG9 sperm associated antigen 9 1 1
MIRT023291 CEACAM8 carcinoembryonic antigen related cell adhesion molecule 8 1 1
MIRT023292 KRT10 keratin 10 1 1
MIRT023293 SET SET nuclear proto-oncogene 1 1
MIRT023294 SLC11A2 solute carrier family 11 member 2 1 1
MIRT023295 MYCBP MYC binding protein 3 3
MIRT023296 GPHB5 glycoprotein hormone beta 5 1 1
MIRT023297 STAU2 staufen double-stranded RNA binding protein 2 1 1
MIRT023298 NFATC1 nuclear factor of activated T-cells 1 1 1
MIRT023299 ERP29 endoplasmic reticulum protein 29 1 1
MIRT023300 MEP1A meprin A subunit alpha 1 1
MIRT023301 SPTLC1 serine palmitoyltransferase long chain base subunit 1 1 1
MIRT023302 GTF2H2 general transcription factor IIH subunit 2 1 1
MIRT023303 C14orf39 chromosome 14 open reading frame 39 1 1
MIRT023304 UBE2K ubiquitin conjugating enzyme E2 K 1 1
MIRT023305 PPP1R9B protein phosphatase 1 regulatory subunit 9B 1 1
MIRT023306 PSMD10 proteasome 26S subunit, non-ATPase 10 1 1
MIRT023307 CALD1 caldesmon 1 1 1
MIRT023308 TTYH3 tweety family member 3 1 1
MIRT023309 NMNAT2 nicotinamide nucleotide adenylyltransferase 2 1 1
MIRT023310 SCN4B sodium voltage-gated channel beta subunit 4 1 1
MIRT023311 C1orf122 chromosome 1 open reading frame 122 1 1
MIRT023312 PAK1 p21 (RAC1) activated kinase 1 1 1
MIRT023313 DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 1 1
MIRT023314 DMXL1 Dmx like 1 1 1
MIRT023315 ZNF160 zinc finger protein 160 1 1
MIRT023316 CSRP1 cysteine and glycine rich protein 1 1 1
MIRT023317 PHKA1 phosphorylase kinase regulatory subunit alpha 1 1 1
MIRT023318 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 1 1
MIRT023319 ANKRD13C ankyrin repeat domain 13C 1 1
MIRT023320 SUCLA2 succinate-CoA ligase ADP-forming beta subunit 1 1
MIRT023321 PEA15 phosphoprotein enriched in astrocytes 15 1 1
MIRT023322 MTPN myotrophin 1 1
MIRT023323 YKT6 YKT6 v-SNARE homolog 1 1
MIRT023324 MOB3B MOB kinase activator 3B 1 1
MIRT023325 FAM118A family with sequence similarity 118 member A 1 1
MIRT023326 ZNF264 zinc finger protein 264 1 1
MIRT023327 HECTD3 HECT domain E3 ubiquitin protein ligase 3 1 1
MIRT023328 BATF2 basic leucine zipper ATF-like transcription factor 2 1 1
MIRT023329 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 1 1
MIRT023330 MAPRE1 microtubule associated protein RP/EB family member 1 1 1
MIRT023331 TBC1D22B TBC1 domain family member 22B 1 1
MIRT023332 SLC9A1 solute carrier family 9 member A1 3 3
MIRT023333 NPEPPS aminopeptidase puromycin sensitive 1 1
MIRT023334 BCL2L1 BCL2 like 1 2 1
MIRT023335 OSMR oncostatin M receptor 1 1
MIRT023336 CALU calumenin 1 1
MIRT023337 BRI3BP BRI3 binding protein 1 1
MIRT023338 PSPH phosphoserine phosphatase 1 1
MIRT023339 APMAP adipocyte plasma membrane associated protein 1 1
MIRT023340 WASF1 WAS protein family member 1 1 1
MIRT023341 LCA5 LCA5, lebercilin 1 1
MIRT023342 NODAL nodal growth differentiation factor 1 1
MIRT023343 CASP7 caspase 7 1 1
MIRT023344 CPA3 carboxypeptidase A3 1 1
MIRT023345 PALM paralemmin 1 1
MIRT023346 TCP11 t-complex 11 1 1
MIRT023347 NALCN sodium leak channel, non-selective 1 1
MIRT023348 PLAGL2 PLAG1 like zinc finger 2 1 1
MIRT023349 IDS iduronate 2-sulfatase 3 3
MIRT023350 PARP11 poly(ADP-ribose) polymerase family member 11 1 1
MIRT023351 MAZ MYC associated zinc finger protein 1 1
MIRT023352 CPNE4 copine 4 1 1
MIRT023353 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 1 1
MIRT023354 KRT14 keratin 14 1 1
MIRT023355 DYNC1H1 dynein cytoplasmic 1 heavy chain 1 1 1
MIRT023356 GNL3L G protein nucleolar 3 like 1 1
MIRT023357 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1 1
MIRT023358 EYA4 EYA transcriptional coactivator and phosphatase 4 1 1
MIRT023359 GNPDA2 glucosamine-6-phosphate deaminase 2 1 1
MIRT023360 BRCA2 BRCA2, DNA repair associated 1 1
MIRT023361 ZSCAN4 zinc finger and SCAN domain containing 4 1 1
MIRT023362 HSPA5 heat shock protein family A (Hsp70) member 5 1 1
MIRT023363 SERAC1 serine active site containing 1 1 1
MIRT023364 SLC15A2 solute carrier family 15 member 2 1 1
MIRT023365 RABIF RAB interacting factor 1 1
MIRT023366 ART3 ADP-ribosyltransferase 3 1 1
MIRT023367 EP400 E1A binding protein p400 1 1
MIRT023368 MT4 metallothionein 4 1 1
MIRT023369 TRAM2 translocation associated membrane protein 2 1 1
MIRT023370 PHPT1 phosphohistidine phosphatase 1 1 1
MIRT023371 KIAA0101 PCNA clamp associated factor 1 1
MIRT023372 VHL von Hippel-Lindau tumor suppressor 1 1
MIRT023373 IFNA1 interferon alpha 1 1 1
MIRT023374 FSTL3 follistatin like 3 1 1
MIRT023375 PHF14 PHD finger protein 14 1 1
MIRT023376 ZCCHC2 zinc finger CCHC-type containing 2 1 1
MIRT023377 GSTM3 glutathione S-transferase mu 3 1 1
MIRT023378 DCTN5 dynactin subunit 5 1 1
MIRT023379 CHST3 carbohydrate sulfotransferase 3 1 1
MIRT023380 HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 1 1
MIRT023381 ADO 2-aminoethanethiol dioxygenase 1 1
MIRT023382 POMZP3 POM121 and ZP3 fusion 1 1
MIRT023383 CHST12 carbohydrate sulfotransferase 12 1 1
MIRT023384 ARSB arylsulfatase B 1 1
MIRT023385 ATP7A ATPase copper transporting alpha 1 1
MIRT023386 PMP22 peripheral myelin protein 22 1 1
MIRT023387 TGFBRAP1 transforming growth factor beta receptor associated protein 1 1 1
MIRT023388 ORC2 origin recognition complex subunit 2 1 1
MIRT023389 CREB1 cAMP responsive element binding protein 1 1 1
MIRT023390 CD83 CD83 molecule 1 1
MIRT023391 TOB2 transducer of ERBB2, 2 3 5
MIRT023392 LRP11 LDL receptor related protein 11 1 1
MIRT023393 MPV17 MPV17, mitochondrial inner membrane protein 1 1
MIRT023394 TRIM29 tripartite motif containing 29 1 1
MIRT023395 OSBP2 oxysterol binding protein 2 1 1
MIRT023396 PKM pyruvate kinase, muscle 6 4
MIRT023397 FOXK2 forkhead box K2 3 3
MIRT023398 CLIC4 chloride intracellular channel 4 5 6
MIRT023399 ST6GALNAC4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 1 1
MIRT023400 SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1 1
MIRT023401 LMNB2 lamin B2 3 5
MIRT023402 BAX BCL2 associated X, apoptosis regulator 2 2
MIRT023403 CDK4 cyclin dependent kinase 4 3 3
MIRT054362 Cux1 cut-like homeobox 1 1 1
MIRT074336 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT109185 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT324745 ACER2 alkaline ceramidase 2 2 2
MIRT325564 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT438005 MEF2D myocyte enhancer factor 2D 1 2
MIRT438206 TGFB1 transforming growth factor beta 1 1 1
MIRT438639 AXL AXL receptor tyrosine kinase 1 1
MIRT438655 NOD2 nucleotide binding oligomerization domain containing 2 3 1
MIRT438734 FUT8 fucosyltransferase 8 3 1
MIRT449879 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT451716 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT453274 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT454113 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT454232 OSBPL10 oxysterol binding protein like 10 2 15
MIRT454344 CDKL1 cyclin dependent kinase like 1 2 2
MIRT455826 ZSWIM1 zinc finger SWIM-type containing 1 2 3
MIRT459903 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 12
MIRT461654 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT461934 TNFSF14 TNF superfamily member 14 2 2
MIRT463834 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT468615 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT469456 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT469637 RAD21 RAD21 cohesin complex component 2 6
MIRT473432 MDM4 MDM4, p53 regulator 2 2
MIRT473872 MAFK MAF bZIP transcription factor K 2 6
MIRT476861 FHL2 four and a half LIM domains 2 2 4
MIRT476893 FBXO21 F-box protein 21 2 2
MIRT479880 CCDC43 coiled-coil domain containing 43 2 2
MIRT488848 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT491164 LRP3 LDL receptor related protein 3 2 2
MIRT497662 PRMT3 protein arginine methyltransferase 3 2 2
MIRT499314 ZNF485 zinc finger protein 485 2 10
MIRT499759 CIRH1A UTP4, small subunit processome component 2 10
MIRT500014 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501090 SLC7A5 solute carrier family 7 member 5 2 4
MIRT509646 ZNF354B zinc finger protein 354B 2 10
MIRT509945 TOMM70A translocase of outer mitochondrial membrane 70 2 6
MIRT510320 SLC2A3 solute carrier family 2 member 3 2 4
MIRT515505 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT516410 COPA coatomer protein complex subunit alpha 2 2
MIRT517861 NCAPD2 non-SMC condensin I complex subunit D2 2 4
MIRT522558 MCAM melanoma cell adhesion molecule 2 4
MIRT523525 GLUL glutamate-ammonia ligase 2 2
MIRT523764 FBXO27 F-box protein 27 2 4
MIRT524517 CDK19 cyclin dependent kinase 19 2 2
MIRT524753 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT529366 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT531189 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531639 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT531913 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532678 PATZ1 POZ/BTB and AT hook containing zinc finger 1 2 2
MIRT533115 YIPF4 Yip1 domain family member 4 2 4
MIRT534740 RBM47 RNA binding motif protein 47 2 2
MIRT535471 PARVB parvin beta 2 4
MIRT536742 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT537237 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT539523 ABCF1 ATP binding cassette subfamily F member 1 2 4
MIRT540438 RBM43 RNA binding motif protein 43 2 2
MIRT542982 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT544674 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT549514 HDDC2 HD domain containing 2 2 2
MIRT549663 ORC6 origin recognition complex subunit 6 2 4
MIRT555420 PPIC peptidylprolyl isomerase C 2 2
MIRT564701 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT570046 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT570257 PRSS16 protease, serine 16 2 2
MIRT571143 HM13 histocompatibility minor 13 2 2
MIRT575202 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT575282 Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT575302 Osbpl10 oxysterol binding protein-like 10 2 9
MIRT575323 Fbxo6 F-box protein 6 2 2
MIRT575377 Ang angiogenin, ribonuclease, RNase A family, 5 2 3
MIRT575614 Zswim1 zinc finger SWIM-type containing 1 2 3
MIRT575671 Map1b microtubule-associated protein 1B 2 2
MIRT607065 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607490 HEBP2 heme binding protein 2 2 2
MIRT607522 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT607655 BTN3A2 butyrophilin subfamily 3 member A2 2 2
MIRT607795 RHBDL2 rhomboid like 2 2 2
MIRT607842 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT607927 ANG angiogenin 2 3
MIRT607966 SNX22 sorting nexin 22 2 2
MIRT608074 ZFP14 ZFP14 zinc finger protein 2 2
MIRT608141 SYAP1 synapse associated protein 1 2 2
MIRT612620 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT617444 CCS copper chaperone for superoxide dismutase 2 2
MIRT617552 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT618772 HLA-E major histocompatibility complex, class I, E 2 2
MIRT618926 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT619247 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT620091 YME1L1 YME1 like 1 ATPase 2 2
MIRT620483 XKR6 XK related 6 2 2
MIRT620570 WBSCR27 methyltransferase like 27 2 4
MIRT622977 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT623169 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624165 DGKE diacylglycerol kinase epsilon 2 2
MIRT625268 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT625396 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT625694 OPTN optineurin 2 2
MIRT626093 MKLN1 muskelin 1 2 2
MIRT626431 CHDH choline dehydrogenase 2 2
MIRT627013 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627077 SF3A1 splicing factor 3a subunit 1 2 2
MIRT627140 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT627347 TSHZ2 teashirt zinc finger homeobox 2 2 2
MIRT627420 THAP2 THAP domain containing 2 2 2
MIRT627441 TAS2R5 taste 2 receptor member 5 2 2
MIRT628078 KAT7 lysine acetyltransferase 7 2 4
MIRT628276 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629094 F2RL1 F2R like trypsin receptor 1 2 2
MIRT629236 CINP cyclin dependent kinase 2 interacting protein 2 2
MIRT629286 UNC13A unc-13 homolog A 2 2
MIRT629407 ADM2 adrenomedullin 2 2 2
MIRT629584 RFC2 replication factor C subunit 2 2 2
MIRT629635 WDR31 WD repeat domain 31 2 2
MIRT629874 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT629984 NARS asparaginyl-tRNA synthetase 2 2
MIRT630043 TERF2 telomeric repeat binding factor 2 2 2
MIRT630061 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT630127 ARHGEF5 Rho guanine nucleotide exchange factor 5 2 2
MIRT630155 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT630252 SMTNL2 smoothelin like 2 2 2
MIRT630278 PSMB5 proteasome subunit beta 5 2 2
MIRT630347 NKAP NFKB activating protein 2 2
MIRT630497 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT631264 CENPM centromere protein M 2 2
MIRT631403 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT632470 RPS15A ribosomal protein S15a 2 2
MIRT632596 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632994 DUSP18 dual specificity phosphatase 18 2 2
MIRT633082 CXorf21 chromosome X open reading frame 21 2 2
MIRT633239 ZNF573 zinc finger protein 573 2 2
MIRT633286 SLC1A5 solute carrier family 1 member 5 2 2
MIRT633536 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634338 SGOL1 shugoshin 1 2 2
MIRT634600 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT635050 MYH11 myosin heavy chain 11 2 2
MIRT635236 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT635322 BMS1 BMS1, ribosome biogenesis factor 2 2
MIRT636268 RNF157 ring finger protein 157 2 2
MIRT636450 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636516 FMN1 formin 1 2 2
MIRT636755 SLC16A5 solute carrier family 16 member 5 2 2
MIRT637134 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT637188 ROMO1 reactive oxygen species modulator 1 2 2
MIRT637287 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT637532 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT637693 CEP89 centrosomal protein 89 2 2
MIRT637788 OLA1 Obg like ATPase 1 2 2
MIRT637925 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT638449 PLXDC2 plexin domain containing 2 2 2
MIRT640871 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT642643 PTGR2 prostaglandin reductase 2 2 2
MIRT643082 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT643123 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644236 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644665 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT645092 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645993 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646508 FAM217B family with sequence similarity 217 member B 2 2
MIRT647013 ADCY2 adenylate cyclase 2 2 2
MIRT647095 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT647714 NFX1 nuclear transcription factor, X-box binding 1 2 4
MIRT648040 FADS6 fatty acid desaturase 6 2 2
MIRT648510 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648865 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT649182 DNPEP aspartyl aminopeptidase 2 2
MIRT649660 TEP1 telomerase associated protein 1 2 2
MIRT651465 XIAP X-linked inhibitor of apoptosis 2 2
MIRT652398 TMEM40 transmembrane protein 40 2 2
MIRT653691 SLC25A33 solute carrier family 25 member 33 2 2
MIRT654122 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654577 PXMP4 peroxisomal membrane protein 4 2 2
MIRT656470 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT658905 DPY19L4 dpy-19 like 4 2 2
MIRT660878 ADRBK2 G protein-coupled receptor kinase 3 2 4
MIRT661101 SPIB Spi-B transcription factor 2 2
MIRT661238 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT661291 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT662235 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662544 MTAP methylthioadenosine phosphorylase 2 2
MIRT662736 LRRC3C leucine rich repeat containing 3C 2 2
MIRT662844 OMD osteomodulin 2 2
MIRT662907 MED18 mediator complex subunit 18 2 2
MIRT662956 JPH2 junctophilin 2 2 2
MIRT663340 ZNF74 zinc finger protein 74 2 2
MIRT663496 IYD iodotyrosine deiodinase 2 2
MIRT663523 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663542 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663903 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT663973 ZNF786 zinc finger protein 786 2 2
MIRT664350 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664417 TIGD6 tigger transposable element derived 6 2 2
MIRT664468 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664957 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT664970 TDRD1 tudor domain containing 1 2 2
MIRT665199 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT665359 XKR4 XK related 4 2 2
MIRT665454 WDR17 WD repeat domain 17 2 2
MIRT665486 VPS53 VPS53, GARP complex subunit 2 2
MIRT666078 SSTR2 somatostatin receptor 2 2 2
MIRT666258 SLC31A1 solute carrier family 31 member 1 2 2
MIRT666324 SLC16A10 solute carrier family 16 member 10 2 2
MIRT666486 SBNO1 strawberry notch homolog 1 2 2
MIRT666696 RBM23 RNA binding motif protein 23 2 2
MIRT666712 RBL1 RB transcriptional corepressor like 1 2 2
MIRT666762 RAB10 RAB10, member RAS oncogene family 2 2
MIRT666931 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT667226 NFE2L1 nuclear factor, erythroid 2 like 1 2 2
MIRT667359 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT667474 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT667558 LRAT lecithin retinol acyltransferase 2 2
MIRT667748 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668088 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT668119 GK5 glycerol kinase 5 (putative) 2 2
MIRT668166 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668346 STXBP2 syntaxin binding protein 2 2 2
MIRT668509 ESYT2 extended synaptotagmin 2 2 2
MIRT669291 C17orf85 nuclear cap binding subunit 3 2 2
MIRT669547 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT669778 CNDP1 carnosine dipeptidase 1 2 2
MIRT669858 BROX BRO1 domain and CAAX motif containing 2 4
MIRT670017 TECPR1 tectonin beta-propeller repeat containing 1 2 2
MIRT670177 CCDC142 coiled-coil domain containing 142 2 2
MIRT671107 ZNF841 zinc finger protein 841 2 2
MIRT671351 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 2
MIRT671476 FLYWCH2 FLYWCH family member 2 2 2
MIRT671492 SLC38A9 solute carrier family 38 member 9 2 2
MIRT671554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT671925 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672196 F2 coagulation factor II, thrombin 2 2
MIRT672217 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT672252 SIK2 salt inducible kinase 2 2 2
MIRT672290 GP2 glycoprotein 2 2 2
MIRT672430 POLR2D RNA polymerase II subunit D 2 2
MIRT672597 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT672901 KRBA2 KRAB-A domain containing 2 2 2
MIRT672958 ZNF655 zinc finger protein 655 2 2
MIRT673096 SYNPO2L synaptopodin 2 like 2 2
MIRT673171 TMEM56 transmembrane protein 56 2 2
MIRT673251 INO80 INO80 complex subunit 2 2
MIRT673296 RNF19B ring finger protein 19B 2 2
MIRT673574 KDELC2 KDEL motif containing 2 2 2
MIRT673586 KIF1C kinesin family member 1C 2 2
MIRT673737 TCF23 transcription factor 23 2 2
MIRT673767 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674215 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT674283 NAGK N-acetylglucosamine kinase 2 2
MIRT674338 KCMF1 potassium channel modulatory factor 1 2 2
MIRT674517 PRR23A proline rich 23A 2 2
MIRT675100 SNTB2 syntrophin beta 2 2 2
MIRT675144 MOGAT1 monoacylglycerol O-acyltransferase 1 2 4
MIRT675223 CLK4 CDC like kinase 4 2 2
MIRT675263 ZNF431 zinc finger protein 431 2 2
MIRT675577 WWC1 WW and C2 domain containing 1 2 2
MIRT676025 C9orf69 transmembrane protein 250 2 2
MIRT676430 PLEKHM3 pleckstrin homology domain containing M3 2 2
MIRT676560 VSIG1 V-set and immunoglobulin domain containing 1 2 2
MIRT676596 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT678576 TMEM168 transmembrane protein 168 2 2
MIRT678756 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT680344 ZNF281 zinc finger protein 281 2 2
MIRT680467 C3 complement C3 2 2
MIRT682826 FLG2 filaggrin family member 2 2 2
MIRT682881 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT684404 TMEM180 major facilitator superfamily domain containing 13A 2 2
MIRT685275 KIAA1143 KIAA1143 2 2
MIRT686061 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT687526 NASP nuclear autoantigenic sperm protein 2 2
MIRT691760 BCL2L15 BCL2 like 15 2 2
MIRT693890 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT699342 SLC35E1 solute carrier family 35 member E1 2 2
MIRT699909 RUNDC1 RUN domain containing 1 2 2
MIRT700536 PTPDC1 protein tyrosine phosphatase domain containing 1 2 2
MIRT701807 MRPS25 mitochondrial ribosomal protein S25 2 2
MIRT702174 LYRM4 LYR motif containing 4 2 2
MIRT706205 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706659 RNF216 ring finger protein 216 2 2
MIRT706682 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT706705 GPR155 G protein-coupled receptor 155 2 2
MIRT706777 ANKRD36 ankyrin repeat domain 36 2 2
MIRT706844 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706863 MAFF MAF bZIP transcription factor F 2 2
MIRT706896 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT706916 THAP6 THAP domain containing 6 2 2
MIRT706962 FANCC Fanconi anemia complementation group C 2 2
MIRT706980 XPO5 exportin 5 2 2
MIRT707015 RRP36 ribosomal RNA processing 36 2 2
MIRT707032 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707072 MED29 mediator complex subunit 29 2 2
MIRT709368 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2 2
MIRT720092 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
MIRT721330 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT724198 MED7 mediator complex subunit 7 2 2
MIRT725403 KIF6 kinesin family member 6 2 2
MIRT733035 COL4A2 collagen type IV alpha 2 chain 1 0
MIRT733036 COL26A1 collagen type XXVI alpha 1 chain 1 0
MIRT733426 PLK1 polo like kinase 1 3 0
MIRT734484 PLD1 phospholipase D1 3 0
MIRT736044 CBL Cbl proto-oncogene 3 0
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