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miRTarBase - #MIRT006177 -
pre-miRNA Information
pre-miRNA hsa-mir-15a   
Genomic Coordinates chr13: 50049119 - 50049201
Synonyms MIRN15A, hsa-mir-15a, miRNA15A, MIR15A
Description Homo sapiens miR-15a stem-loop
Comment Reference .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-15a-5p
Sequence 14| UAGCAGCACAUAAUGGUUUGUG |35
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1355089203 8 dbSNP
rs753467375 11 dbSNP
rs923737993 12 dbSNP
rs766120172 20 dbSNP
rs1359939022 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles

Circulating MicroRNA Expression Profiling
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CRKL   
Synonyms -
Description CRK like proto-oncogene, adaptor protein
Transcript NM_005207   
Expression
Putative miRNA Targets on CRKL
3'UTR of CRKL
(miRNA target sites are highlighted)
>CRKL|NM_005207|3'UTR
   1 TTGCTGTTGCCCTGTTTCCTGCTGCTTTGTTGTTCTGCCTGTCCTAGTCTCCTTTGAAGTGGGAAAGCATTTTCTCTCAT
  81 AGGCAAGTCACACTGCATTGCCGAAGTCCAGCTTTCTGCAGACTGGCAGTCGCACACACATTTGGAATGCACACAGCGGC
 161 TGCCTCCTGATGTTTGTATCATAGTCGTATTGTCAAAGAGTAGCCGATTTTAGAGTTCTTTTGGATCATAAACTGGAAAT
 241 ACTGATGGAAGCACACAAGTGGAGAGAAGTTGACATGGAAAGGGTCTTCCTTCTCATTGCTGCCCGTTTGTACATGGGAC
 321 TGATTCTGTTGTGTTCACCAGAGAAAGCTTGAGGCCATGGCGAGATACTGCATGTTTGCTGTTCCACAAAGCAGTGGCTT
 401 AGCTGCCATCTTGCTTTTCTTTGGACAACAGGAAGTGAACCTTAAGGAAGAGAGAATTCTGTTCTAAAACTCCAAAATCT
 481 GGCTTTTTTTTTTCTTTTGTTTTGGTTTGGTTTTGGAAAACTAATTAATTAGACTTGTGTGGGGGTTTTTTTTTGTTTTG
 561 TTTTGTTTGTTTTGTTTTGTTTTTTTGAGACGGTGTCTCGCTGCATCACCCAGGCTGGAGTGCAGTGGCGCAATCTCGCC
 641 TTCCTGCAGTCTCCGCCTCCTGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTGCAGGCGCGCACA
 721 CCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCATCATGTTGACCAGGCTGGTCTCAAACTCCTGACTT
 801 CAGGTGATCCACCCGCCTTCAGCCTCCCAACGTGCTGGGATTACAGCCGTGAGCCGCCGCGCCTGGCCTAGACTTGTGTG
 881 TTCTAAACAGGTTAAGTAGCAGGTTGGGTTTTTATGATAGTGCAAGGAATGACTCATGCCTCTGAGCTTCTAAACTGAAG
 961 CTGCTGTAACTAAAGGAATCTGAAAAGAACAACCCTGAAGCAGAGGCCTTTATTGTCTTGGTTGCCAGTAGTACCTTGTT
1041 TTGCCATGTAGCAGACAACACACAAAATAATGCAGTTGTGGTGTGCCATGCTATGTGCACAGCCCCTTGGATTACTTTGT
1121 TTTAAAAAGCATCAGAGTTGGGGGTACTTTAGGGAAACCTTTGCTTACCTTGTTTTGCCAGTGATAAGAGCAGTGGGTTG
1201 GAGGGCACTTGGCCAGTTTTCTGTTCAGCTTTTCAGTGAATGTACCCCTTTAAGGTTCAGACTTAAACTTCCTTAAAAAG
1281 TGGCGTTGTTCATAGAATCGTTGGACTCATTAATGAATCGTTCAACTCCACTCACTGAAGCCCAGACCTCCGTGCCCAGG
1361 CCCAATCTCGTCAGGCTGCCAGAGAAAGTTGGTGCTGCTCATACTGGTCTCACAGTCTAAGTAAGTGTCTGTGATGCTCC
1441 CAAGCAAAGGAAATGCAAGCTCTGGAAATTCGTTAATGTATTTGATGTCTTAGTGTTTTAGTGACTAGGGAGACCATTAA
1521 CTAGTTTATCATTAACCACTTATCAGTGTATTGATGTTAAAGCATTTCCCTGTTAGCTAAAAGAGGCCTGTTCATACAAG
1601 CCAACTGGTATATACGTGTGGTTCATCCATCATCTGCTGCACATAGCAGACTAGAATTCTGGGAACCCTGTGCAATTCAG
1681 TCTGCTCTCCCTTGTGGACCCTGGTAAAGAAAAGCCTCAGCTCATAGTGAACACAGCAGACCTAGAAATGTAGCAGCAGC
1761 CTACTGAGTAGCTTTCATTTACTGATCATCTGCTGTGACTGTGGCCCTGTCTGGAGGTTCCTAGGTTTTGAGATTTAGAG
1841 CAATGCATTCTGGAGACAGAACCAGCAGAACAGCCATTTTTCAATTTTTCTTTAAATCAGTATTCCATCAGGCAGATAAC
1921 TGCTGTATTCATGAATCTTGAGAGTGTTCCTGAGACAGAATTAATGGTCATTTGGGAAAACTATCGCCATGGCTTCCCAT
2001 CTGTGGTTTTCCTCTAAAAGCCTTGGAGATTAGCCCTTCCTTGCCAGTGAGAACGGTGACCGCCTCCTGCTCTGCACGGT
2081 CTGCGGCAGTTGCCGCTTCTGGTTAGGTGTGTCAGGTTGGCTTATTTTGGGTTCAGGCCTGGCGTAGCACCCACAAGTGG
2161 CAGACATATCACAAGAGTCCCCAGACTCTGCCTAGAAACAGTGTTTGCCCTTTGGCCAGTGACGTGGTTCATCCCGGCCC
2241 ATGTTGAGCCATGAGTGGAGTTTCCAACAGAGGGAGGAATGTGTGCCTTGTTCAAGGAGGGCACGACCCTTAGGCCTTTT
2321 TCAACCAGATTTAGCTGAAGGGCTTGACACCTTTGAATTACAGCAGTTGACTCAGAGTGCAAGAAGTCTGGCCATTTTGG
2401 AAAGCAAGGTTTCCTTTCAGCCCTGTCTACTGACCAATACCCCGACTCACCTTGTGTGGCGCACTTCAGAATCAGATATA
2481 CCTAGAGTATACCTGTGGTTTGGTTTTATAATTAATCAGCTCGTTACTTCAGCCCATGAAAATGGCATCCAGGGCTGCCA
2561 GGAGATTCAGAGCTCAAAACAAGGCGAGCTTGAGTTCTGCACTCCAGATATGTGCCAAAACTAGTAAAACTTAACGGACT
2641 TACAACCTTGTCAGTTTTTTTAATGAGGCAGGGATACTCTGTTTTTCACACTAAACATATGAATGCAGCACTGCTGCCTC
2721 AGCTCAGCTTCGTGCCTGGGTTCCCCACTGGTCTGGGAAGACTGTTGTGCTCCATAGAGCAGTGCACATCTGACCCAGAG
2801 GGTGGGTGTTCATAACTGCTACTTGCTCTGCTCTACCATGTTTAAAGAAATATTTGGATGTTAAATTAACTCACTATGGT
2881 TTTTCACCTGGGAAGGAAACAAATTACGTACTAGAGGGCATTGACTGGTTAAAAACTTGTGTATCCCGGGAAGGACCTGC
2961 GGTACAGGAGTCAGCCATGTCTGTGCTGTGTGGAACCACCTGATGACATGGTTAACGAGGAAGACGATGTGTTGACCGGC
3041 TGCCGTTTGAGGACTTTGGTCACCCAGACTAGACACCTTCTGTGCTCATGTTTGGAAAGCTGAAAGGGAAGGACAGCTGT
3121 GCCCTCCTGGGAGCTCATGTGTCCCTGGCGCTGTGCTAGCTTTCCTTTACAGCTGTTTACAGACAAGGCAGGCCTGAGGC
3201 AGATGGCCACTGCTCTTGTGATGTTTGCTCAGAGGAATATGAACATTTTATTTTTGAAAAGGGATGATGTGGTTTTTTGC
3281 CAGGTGTTTATAATTAATCCTTTAATATTATGGTTATTAACCTCTTAAACATGAATGAATTCTTGATTGTTTTAACACAG
3361 TACCTAAGACTAATGCTTTCTGTGGACACCACTGAGCTCTGCCTCAACTCCACCCTCTGCGACCGGAGGACTATGCCCCT
3441 AGTAACTGCTGTCGGTGTGGACGCTGTGCTGGTTCTGTTTTCTAAAGGAGCAGAAGGACAGGTCTCTGAGACAGGATCGT
3521 TGTCCCTACAGGAGGAACAGTGGCCTTGCTTCTTAGACGGTCTTCACTGTGTGTTTTAAAACAACAACAACAACAACAAC
3601 AACAACATAAAACTCTTTTGACCTGTAACTTAAAGATCATAAACTTCAGGCAATAATATTTTCTGTGTAAGCTTTTAAAA
3681 TTATTTTTGGGGATCATAGCTTGTTTTATTTTGTGCTATAAAATTAACAGTATTAAATGACTTATATTCTTAGAATACAT
3761 CGAGTGTCTTTTCTTAACAGATTAGTGCCTTTTTATTTTTGTATTCCGTTTTACGTTACTGGTCCCAGCATCAAAACCCT
3841 TGTTTCCATGGCCTGTTTGTATATTGTCTCAATAAAACTTGCATCAGCCGGTGGTGGCGGCAGCAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1
miRNA  3' gugUUUGGUAAUACACGACGAu 5'
             |:|  :||: |||||||| 
Target 5' cagAGAAAGTTG-GTGCTGCTc 3'
1380 - 1400 154.00 -15.00
2
miRNA  3' guguuuGGUAAUACACGACGAu 5'
                |::||   ||||||| 
Target 5' gttgccCTGTTTCCTGCTGCTt 3'
6 - 27 148.00 -10.70
3
miRNA  3' guguUUGGUAAUACACGACGau 5'
              | |||| || ||||||  
Target 5' gttcATCCATCATCTGCTGCac 3'
1621 - 1642 146.00 -12.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30152205 14 COSMIC
COSN26565212 62 COSMIC
COSN30162707 75 COSMIC
COSN30494465 77 COSMIC
COSN25180772 133 COSMIC
COSN31575748 136 COSMIC
COSN30511189 175 COSMIC
COSN31570583 207 COSMIC
COSN30137283 217 COSMIC
COSN1259459 253 COSMIC
COSN20117162 494 COSMIC
COSN1259460 495 COSMIC
COSN9161964 546 COSMIC
COSN29372788 715 COSMIC
COSN31961946 988 COSMIC
COSN17075706 1201 COSMIC
COSN21492652 1415 COSMIC
COSN22448442 1554 COSMIC
COSN21660247 1584 COSMIC
COSN31562665 2493 COSMIC
COSN22588846 2632 COSMIC
COSN31563154 2638 COSMIC
COSN31577194 2698 COSMIC
COSN17337516 2754 COSMIC
COSN31548132 2827 COSMIC
COSN1259461 3100 COSMIC
COSN28813562 3188 COSMIC
COSN1895149 3284 COSMIC
COSN31546984 3371 COSMIC
COSN32064240 3455 COSMIC
COSN8346385 3519 COSMIC
COSN23713815 3580 COSMIC
COSN20117167 3606 COSMIC
COSN20117166 3608 COSMIC
COSN31579223 3666 COSMIC
COSN31538039 3763 COSMIC
COSN26171823 3838 COSMIC
COSN26170622 3858 COSMIC
rs117003805 1714 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs993387735 2 dbSNP
rs1463700584 4 dbSNP
rs1327696332 7 dbSNP
rs1035280926 10 dbSNP
rs1395013800 13 dbSNP
rs1385985046 18 dbSNP
rs1299192111 19 dbSNP
rs754239104 22 dbSNP
rs1229704391 23 dbSNP
rs763362875 26 dbSNP
rs759848266 36 dbSNP
rs373218389 37 dbSNP
rs765462541 42 dbSNP
rs752850306 49 dbSNP
rs758615647 51 dbSNP
rs962435561 60 dbSNP
rs973515333 81 dbSNP
rs1439116826 82 dbSNP
rs959738886 86 dbSNP
rs560990413 93 dbSNP
rs769177194 95 dbSNP
rs1237242957 103 dbSNP
rs1437405635 105 dbSNP
rs920559358 107 dbSNP
rs747678003 118 dbSNP
rs969942007 121 dbSNP
rs202127561 131 dbSNP
rs878948440 132 dbSNP
rs1287960932 133 dbSNP
rs1208427278 138 dbSNP
rs979599831 139 dbSNP
rs1304052915 140 dbSNP
rs911122423 149 dbSNP
rs943995115 159 dbSNP
rs771582414 164 dbSNP
rs1324767763 168 dbSNP
rs1398525056 173 dbSNP
rs530023569 174 dbSNP
rs549067426 178 dbSNP
rs891668341 182 dbSNP
rs772959264 187 dbSNP
rs566056236 188 dbSNP
rs1040176667 197 dbSNP
rs1260707544 201 dbSNP
rs1176078449 206 dbSNP
rs899893281 207 dbSNP
rs748417301 219 dbSNP
rs1376200013 223 dbSNP
rs1042821625 235 dbSNP
rs35335239 235 dbSNP
rs535066674 244 dbSNP
rs1428793048 245 dbSNP
rs1264876687 249 dbSNP
rs1001175294 256 dbSNP
rs1034001863 258 dbSNP
rs760366910 262 dbSNP
rs1232982264 270 dbSNP
rs766255001 271 dbSNP
rs1014542916 272 dbSNP
rs1250868289 275 dbSNP
rs737894 276 dbSNP
rs962244774 278 dbSNP
rs547902233 280 dbSNP
rs753116903 282 dbSNP
rs1342059682 284 dbSNP
rs1356534568 296 dbSNP
rs1195913893 297 dbSNP
rs1027758624 298 dbSNP
rs1396369436 303 dbSNP
rs1166884063 306 dbSNP
rs1462039018 311 dbSNP
rs1425079531 314 dbSNP
rs571806225 315 dbSNP
rs1258021453 316 dbSNP
rs545959252 316 dbSNP
rs537609450 319 dbSNP
rs189640104 321 dbSNP
rs1253174456 329 dbSNP
rs1548410 331 dbSNP
rs978924259 332 dbSNP
rs1196450712 339 dbSNP
rs1374758687 340 dbSNP
rs1232919604 341 dbSNP
rs1032470801 351 dbSNP
rs1475716627 358 dbSNP
rs956895996 362 dbSNP
rs17212305 363 dbSNP
rs114248326 370 dbSNP
rs944308625 373 dbSNP
rs1328256050 374 dbSNP
rs1401886230 381 dbSNP
rs572500671 382 dbSNP
rs1162143268 384 dbSNP
rs12628354 387 dbSNP
rs1391710532 391 dbSNP
rs1418114620 395 dbSNP
rs913023853 398 dbSNP
rs1299605606 402 dbSNP
rs1328528774 407 dbSNP
rs1468418925 409 dbSNP
rs945916396 411 dbSNP
rs533878900 415 dbSNP
rs1458994852 418 dbSNP
rs183405299 419 dbSNP
rs1213117037 429 dbSNP
rs937120875 438 dbSNP
rs1292279844 449 dbSNP
rs1055381400 450 dbSNP
rs1222222599 451 dbSNP
rs1350417371 455 dbSNP
rs1234575530 464 dbSNP
rs1280463588 465 dbSNP
rs1242981003 471 dbSNP
rs1265711250 472 dbSNP
rs1369388224 474 dbSNP
rs895488034 475 dbSNP
rs1439501351 483 dbSNP
rs1383995720 484 dbSNP
rs1398550189 484 dbSNP
rs200139060 484 dbSNP
rs398081677 484 dbSNP
rs60913011 484 dbSNP
rs908376727 491 dbSNP
rs397819599 494 dbSNP
rs200621487 495 dbSNP
rs939884683 495 dbSNP
rs1193154735 498 dbSNP
rs1447305489 500 dbSNP
rs1014887127 501 dbSNP
rs1192857067 504 dbSNP
rs1421383889 505 dbSNP
rs867625059 516 dbSNP
rs1056958276 518 dbSNP
rs1416283591 522 dbSNP
rs895713102 522 dbSNP
rs558215893 523 dbSNP
rs1303328535 535 dbSNP
rs575011073 538 dbSNP
rs994996415 539 dbSNP
rs1369312030 540 dbSNP
rs1367729319 541 dbSNP
rs1276053848 543 dbSNP
rs1428270276 544 dbSNP
rs1421278031 546 dbSNP
rs544048902 546 dbSNP
rs904188858 546 dbSNP
rs1373334205 547 dbSNP
rs1031456549 550 dbSNP
rs1184834341 551 dbSNP
rs59011694 551 dbSNP
rs1019809338 552 dbSNP
rs1475247091 552 dbSNP
rs529888353 556 dbSNP
rs1291956600 557 dbSNP
rs1007685542 561 dbSNP
rs1212248445 562 dbSNP
rs368709446 562 dbSNP
rs572061085 562 dbSNP
rs1018919372 564 dbSNP
rs187614589 566 dbSNP
rs567863750 566 dbSNP
rs976072908 566 dbSNP
rs977047184 570 dbSNP
rs913167982 571 dbSNP
rs1234634327 580 dbSNP
rs1448732957 580 dbSNP
rs1360822482 582 dbSNP
rs1409467343 590 dbSNP
rs1312844196 591 dbSNP
rs879302997 591 dbSNP
rs190588920 592 dbSNP
rs1474318936 596 dbSNP
rs1242176940 598 dbSNP
rs183479700 600 dbSNP
rs1231660991 601 dbSNP
rs1204375470 605 dbSNP
rs925823715 610 dbSNP
rs937089856 616 dbSNP
rs1261004828 622 dbSNP
rs1220114232 623 dbSNP
rs984156013 625 dbSNP
rs1292494273 630 dbSNP
rs188333956 631 dbSNP
rs553642758 633 dbSNP
rs571739083 634 dbSNP
rs1441341648 636 dbSNP
rs1036460553 638 dbSNP
rs193003105 639 dbSNP
rs751862979 645 dbSNP
rs199836325 650 dbSNP
rs948623120 655 dbSNP
rs184656524 656 dbSNP
rs1177171370 658 dbSNP
rs889288385 661 dbSNP
rs904179834 665 dbSNP
rs1420743501 668 dbSNP
rs1158381606 669 dbSNP
rs1358976955 672 dbSNP
rs1007617008 673 dbSNP
rs1417182128 683 dbSNP
rs1303876441 686 dbSNP
rs567840743 694 dbSNP
rs1393786791 696 dbSNP
rs1308768929 708 dbSNP
rs1223191855 709 dbSNP
rs1019055157 714 dbSNP
rs536495152 715 dbSNP
rs1239208163 716 dbSNP
rs1283662434 717 dbSNP
rs1052789936 721 dbSNP
rs150480292 724 dbSNP
rs1009553159 725 dbSNP
rs1021402735 726 dbSNP
rs1255273332 731 dbSNP
rs1440892919 741 dbSNP
rs868823505 750 dbSNP
rs1483007683 751 dbSNP
rs1452036060 757 dbSNP
rs566860260 758 dbSNP
rs1210086761 760 dbSNP
rs1489242862 764 dbSNP
rs1258780104 770 dbSNP
rs1215618753 778 dbSNP
rs774386531 781 dbSNP
rs1354392626 788 dbSNP
rs138659879 791 dbSNP
rs377709552 791 dbSNP
rs1231910241 793 dbSNP
rs1370388717 795 dbSNP
rs978689840 796 dbSNP
rs1302015773 802 dbSNP
rs1032772245 811 dbSNP
rs1388796820 812 dbSNP
rs891525154 815 dbSNP
rs538214183 816 dbSNP
rs1420706420 831 dbSNP
rs1008661891 832 dbSNP
rs757554478 833 dbSNP
rs558152517 836 dbSNP
rs916987677 839 dbSNP
rs1178204959 845 dbSNP
rs574948297 849 dbSNP
rs949866428 850 dbSNP
rs1488498393 853 dbSNP
rs1378862943 855 dbSNP
rs971747057 856 dbSNP
rs570361391 857 dbSNP
rs554414375 860 dbSNP
rs370855350 861 dbSNP
rs952723146 862 dbSNP
rs1235511941 863 dbSNP
rs1306043614 877 dbSNP
rs1295128425 884 dbSNP
rs750800364 895 dbSNP
rs9625171 900 dbSNP
rs1342798253 904 dbSNP
rs908562732 907 dbSNP
rs1299355154 915 dbSNP
rs57573660 917 dbSNP
rs1467142976 918 dbSNP
rs943538774 924 dbSNP
rs1040967808 926 dbSNP
rs1169561935 927 dbSNP
rs917085502 928 dbSNP
rs1445610432 932 dbSNP
rs1185492516 943 dbSNP
rs1306561689 952 dbSNP
rs1441837760 961 dbSNP
rs1256761057 962 dbSNP
rs1337565799 964 dbSNP
rs1257449897 966 dbSNP
rs761951740 967 dbSNP
rs377011515 976 dbSNP
rs1320227571 978 dbSNP
rs1372918894 991 dbSNP
rs532467614 993 dbSNP
rs1341383171 994 dbSNP
rs948592301 1000 dbSNP
rs1390131756 1008 dbSNP
rs1393725276 1010 dbSNP
rs1330070298 1019 dbSNP
rs980026883 1029 dbSNP
rs1425322279 1034 dbSNP
rs925841084 1036 dbSNP
rs935919866 1045 dbSNP
rs1310332526 1057 dbSNP
rs1368787010 1060 dbSNP
rs1189561494 1066 dbSNP
rs1435984652 1073 dbSNP
rs1237690189 1078 dbSNP
rs545372340 1080 dbSNP
rs1206485522 1082 dbSNP
rs1260098386 1083 dbSNP
rs1458220560 1086 dbSNP
rs565285662 1088 dbSNP
rs901914571 1090 dbSNP
rs1052740300 1091 dbSNP
rs530970637 1094 dbSNP
rs1357536501 1103 dbSNP
rs1010099940 1107 dbSNP
rs1236574922 1115 dbSNP
rs11913242 1125 dbSNP
rs1286273132 1129 dbSNP
rs1237592597 1139 dbSNP
rs1376775033 1141 dbSNP
rs1479242004 1147 dbSNP
rs186924008 1151 dbSNP
rs1446867765 1154 dbSNP
rs891471065 1171 dbSNP
rs780568915 1172 dbSNP
rs1404340341 1178 dbSNP
rs747624627 1181 dbSNP
rs1425133380 1186 dbSNP
rs1164748728 1187 dbSNP
rs1040562598 1189 dbSNP
rs73392523 1196 dbSNP
rs1179111198 1210 dbSNP
rs1441625228 1236 dbSNP
rs1251178555 1237 dbSNP
rs1000039785 1238 dbSNP
rs1032907980 1252 dbSNP
rs530300574 1256 dbSNP
rs138343678 1261 dbSNP
rs991268483 1263 dbSNP
rs1292523311 1284 dbSNP
rs1203750370 1285 dbSNP
rs777279089 1285 dbSNP
rs763897430 1286 dbSNP
rs1028508624 1289 dbSNP
rs888667303 1292 dbSNP
rs971166297 1293 dbSNP
rs1005765955 1300 dbSNP
rs1272548826 1300 dbSNP
rs566796996 1301 dbSNP
rs1015506722 1321 dbSNP
rs972225371 1326 dbSNP
rs1417643615 1331 dbSNP
rs9613388 1341 dbSNP
rs770494981 1352 dbSNP
rs1421391384 1359 dbSNP
rs558089316 1362 dbSNP
rs985019646 1366 dbSNP
rs970187632 1370 dbSNP
rs576482420 1371 dbSNP
rs1488171315 1375 dbSNP
rs1264301137 1385 dbSNP
rs1256454877 1387 dbSNP
rs568510220 1390 dbSNP
rs149555262 1401 dbSNP
rs191277182 1405 dbSNP
rs1246514900 1406 dbSNP
rs1218111849 1407 dbSNP
rs1345032301 1411 dbSNP
rs370284592 1414 dbSNP
rs555511198 1417 dbSNP
rs1339622302 1418 dbSNP
rs1487677541 1418 dbSNP
rs935866720 1420 dbSNP
rs1040539139 1422 dbSNP
rs1175523726 1423 dbSNP
rs902049313 1430 dbSNP
rs1167895325 1432 dbSNP
rs867971486 1435 dbSNP
rs1168842447 1439 dbSNP
rs945442142 1440 dbSNP
rs1424833536 1441 dbSNP
rs1196289760 1442 dbSNP
rs944383932 1456 dbSNP
rs1237424167 1464 dbSNP
rs764645414 1470 dbSNP
rs903838699 1472 dbSNP
rs533959023 1473 dbSNP
rs769818290 1478 dbSNP
rs554009915 1485 dbSNP
rs577165732 1492 dbSNP
rs1339730250 1500 dbSNP
rs1055076931 1503 dbSNP
rs894387350 1504 dbSNP
rs775612009 1508 dbSNP
rs1013285839 1510 dbSNP
rs1050316803 1511 dbSNP
rs375222775 1514 dbSNP
rs762925828 1516 dbSNP
rs1229117494 1517 dbSNP
rs993234184 1527 dbSNP
rs562821285 1541 dbSNP
rs144243028 1544 dbSNP
rs1422438495 1549 dbSNP
rs1413472728 1551 dbSNP
rs1219233460 1563 dbSNP
rs1474048115 1577 dbSNP
rs1238743622 1578 dbSNP
rs1014187468 1595 dbSNP
rs751591534 1596 dbSNP
rs1258324814 1598 dbSNP
rs762033843 1605 dbSNP
rs1319739819 1612 dbSNP
rs970515630 1616 dbSNP
rs910254485 1617 dbSNP
rs964956585 1625 dbSNP
rs976745143 1626 dbSNP
rs1381244183 1628 dbSNP
rs1307242989 1637 dbSNP
rs1446143600 1639 dbSNP
rs1472800969 1640 dbSNP
rs1033257776 1641 dbSNP
rs1456537226 1643 dbSNP
rs1349710184 1647 dbSNP
rs957225698 1651 dbSNP
rs57484744 1652 dbSNP
rs1411162098 1656 dbSNP
rs375244998 1661 dbSNP
rs1238214615 1667 dbSNP
rs1421336809 1674 dbSNP
rs913176906 1676 dbSNP
rs1487290042 1687 dbSNP
rs965969131 1688 dbSNP
rs780669705 1690 dbSNP
rs945553353 1692 dbSNP
rs1042583917 1696 dbSNP
rs976124723 1701 dbSNP
rs561400042 1702 dbSNP
rs1283798144 1704 dbSNP
rs1359615312 1707 dbSNP
rs117003805 1714 dbSNP
rs1055044472 1716 dbSNP
rs1377771690 1724 dbSNP
rs895151250 1725 dbSNP
rs750745536 1728 dbSNP
rs564770745 1736 dbSNP
rs865884949 1739 dbSNP
rs1367167341 1749 dbSNP
rs1294545851 1754 dbSNP
rs910043762 1764 dbSNP
rs1358955250 1765 dbSNP
rs1158610281 1775 dbSNP
rs369234111 1778 dbSNP
rs1448848706 1788 dbSNP
rs1420792009 1801 dbSNP
rs1046071247 1806 dbSNP
rs1160646568 1808 dbSNP
rs1431148167 1809 dbSNP
rs941559239 1814 dbSNP
rs1266244080 1822 dbSNP
rs1377227288 1841 dbSNP
rs1191342173 1842 dbSNP
rs1490788339 1846 dbSNP
rs937829045 1848 dbSNP
rs907013951 1850 dbSNP
rs1260704900 1851 dbSNP
rs993720673 1854 dbSNP
rs1287213320 1856 dbSNP
rs1353363582 1859 dbSNP
rs780517938 1860 dbSNP
rs897384643 1865 dbSNP
rs184989297 1866 dbSNP
rs1302250763 1869 dbSNP
rs112216359 1870 dbSNP
rs1338938895 1882 dbSNP
rs1046107870 1885 dbSNP
rs368777340 1896 dbSNP
rs951770677 1896 dbSNP
rs1401189892 1903 dbSNP
rs754429501 1908 dbSNP
rs1301541074 1909 dbSNP
rs1464105846 1924 dbSNP
rs905905244 1925 dbSNP
rs1006014765 1926 dbSNP
rs1186195909 1931 dbSNP
rs1192662862 1936 dbSNP
rs1488610616 1939 dbSNP
rs1002017741 1945 dbSNP
rs1441196517 1946 dbSNP
rs1482987174 1959 dbSNP
rs1256618539 1982 dbSNP
rs532613829 1986 dbSNP
rs552431165 1987 dbSNP
rs1010051538 1988 dbSNP
rs1020141704 1990 dbSNP
rs1219647216 1994 dbSNP
rs964741331 2000 dbSNP
rs976027447 2002 dbSNP
rs921592058 2004 dbSNP
rs976337040 2016 dbSNP
rs923498305 2030 dbSNP
rs1302884211 2038 dbSNP
rs1470789401 2039 dbSNP
rs1397659231 2048 dbSNP
rs967015748 2054 dbSNP
rs372052771 2055 dbSNP
rs1437520329 2056 dbSNP
rs189274432 2062 dbSNP
rs925491455 2063 dbSNP
rs936717110 2075 dbSNP
rs777271857 2078 dbSNP
rs1037129479 2079 dbSNP
rs1169613040 2082 dbSNP
rs916550341 2082 dbSNP
rs1456453611 2085 dbSNP
rs1257667748 2086 dbSNP
rs1403954836 2094 dbSNP
rs116709245 2095 dbSNP
rs1310170406 2096 dbSNP
rs3171744 2097 dbSNP
rs1341586658 2114 dbSNP
rs568098676 2115 dbSNP
rs1376709833 2123 dbSNP
rs1046418027 2132 dbSNP
rs907103655 2139 dbSNP
rs929275841 2140 dbSNP
rs905845998 2142 dbSNP
rs575162167 2145 dbSNP
rs887612388 2155 dbSNP
rs553946602 2165 dbSNP
rs781624578 2170 dbSNP
rs544163986 2172 dbSNP
rs893196171 2175 dbSNP
rs1010332916 2193 dbSNP
rs1020089504 2195 dbSNP
rs1237587709 2196 dbSNP
rs1437932357 2196 dbSNP
rs1179549369 2198 dbSNP
rs539676517 2200 dbSNP
rs376149893 2201 dbSNP
rs1209601049 2210 dbSNP
rs1357426483 2215 dbSNP
rs1238560319 2224 dbSNP
rs1294594633 2224 dbSNP
rs997577316 2225 dbSNP
rs997833498 2231 dbSNP
rs139100081 2234 dbSNP
rs533624313 2236 dbSNP
rs1337161985 2237 dbSNP
rs1437657900 2243 dbSNP
rs746519194 2244 dbSNP
rs770663498 2245 dbSNP
rs1200709485 2247 dbSNP
rs1378176868 2248 dbSNP
rs1477677092 2252 dbSNP
rs1165414002 2261 dbSNP
rs1043235 2268 dbSNP
rs561130450 2275 dbSNP
rs1015892516 2277 dbSNP
rs574836156 2284 dbSNP
rs971830077 2297 dbSNP
rs990839609 2306 dbSNP
rs1452580622 2311 dbSNP
rs34507581 2313 dbSNP
rs916646869 2314 dbSNP
rs143115509 2316 dbSNP
rs181747193 2325 dbSNP
rs918749571 2326 dbSNP
rs117779512 2329 dbSNP
rs1284774141 2332 dbSNP
rs1223842851 2338 dbSNP
rs1352128131 2343 dbSNP
rs1272747569 2345 dbSNP
rs918636951 2351 dbSNP
rs1304696078 2352 dbSNP
rs185457677 2362 dbSNP
rs1398145159 2363 dbSNP
rs1359808264 2366 dbSNP
rs1318819569 2374 dbSNP
rs1390067606 2374 dbSNP
rs112867627 2381 dbSNP
rs1423104086 2395 dbSNP
rs887582814 2400 dbSNP
rs775561225 2406 dbSNP
rs563167293 2408 dbSNP
rs1038914103 2413 dbSNP
rs557582988 2414 dbSNP
rs937604634 2423 dbSNP
rs1488284859 2426 dbSNP
rs777691656 2430 dbSNP
rs577414383 2441 dbSNP
rs900241854 2444 dbSNP
rs762877950 2445 dbSNP
rs1275864192 2455 dbSNP
rs1030369190 2459 dbSNP
rs1323799716 2461 dbSNP
rs548125656 2462 dbSNP
rs1216581732 2475 dbSNP
rs902182842 2478 dbSNP
rs1270731096 2480 dbSNP
rs1432750452 2483 dbSNP
rs1211227863 2486 dbSNP
rs1333559831 2493 dbSNP
rs768487862 2495 dbSNP
rs1408562295 2496 dbSNP
rs1032572980 2509 dbSNP
rs774439923 2520 dbSNP
rs1477715292 2524 dbSNP
rs567951291 2534 dbSNP
rs533820399 2540 dbSNP
rs1472076783 2562 dbSNP
rs761830033 2562 dbSNP
rs946108445 2566 dbSNP
rs1041856616 2567 dbSNP
rs1461330714 2569 dbSNP
rs901659858 2586 dbSNP
rs990936427 2587 dbSNP
rs1317092392 2589 dbSNP
rs997381886 2595 dbSNP
rs1478870721 2601 dbSNP
rs34881868 2604 dbSNP
rs1029260099 2605 dbSNP
rs547496077 2607 dbSNP
rs1043242 2611 dbSNP
rs1385002899 2618 dbSNP
rs868039291 2622 dbSNP
rs1006097988 2623 dbSNP
rs918549148 2636 dbSNP
rs189984591 2637 dbSNP
rs117644779 2640 dbSNP
rs1024752644 2644 dbSNP
rs1184678408 2651 dbSNP
rs970904166 2655 dbSNP
rs981607242 2671 dbSNP
rs1176450631 2673 dbSNP
rs927460273 2677 dbSNP
rs1271197060 2680 dbSNP
rs909114658 2680 dbSNP
rs937568141 2686 dbSNP
rs990438149 2690 dbSNP
rs914565896 2691 dbSNP
rs1319645267 2695 dbSNP
rs58561717 2698 dbSNP
rs901903065 2701 dbSNP
rs1361740329 2710 dbSNP
rs1038883331 2713 dbSNP
rs546381663 2715 dbSNP
rs1446404964 2721 dbSNP
rs921790436 2726 dbSNP
rs933028735 2727 dbSNP
rs1434767149 2728 dbSNP
rs1051533621 2732 dbSNP
rs140499593 2733 dbSNP
rs555674963 2738 dbSNP
rs1053415205 2741 dbSNP
rs1213368896 2751 dbSNP
rs574720057 2751 dbSNP
rs894055289 2754 dbSNP
rs1250817137 2768 dbSNP
rs1178512288 2773 dbSNP
rs1012494247 2775 dbSNP
rs993103020 2783 dbSNP
rs1355448082 2784 dbSNP
rs1024187097 2786 dbSNP
rs11544581 2788 dbSNP
rs970928094 2795 dbSNP
rs1490818309 2800 dbSNP
rs1219945179 2802 dbSNP
rs1265295175 2803 dbSNP
rs568006410 2806 dbSNP
rs1356379721 2807 dbSNP
rs1488593689 2809 dbSNP
rs1192787609 2810 dbSNP
rs1309462659 2812 dbSNP
rs1025077012 2817 dbSNP
rs540264086 2819 dbSNP
rs1407371341 2827 dbSNP
rs1274593661 2831 dbSNP
rs1426743449 2832 dbSNP
rs1025746731 2833 dbSNP
rs754158311 2835 dbSNP
rs1189958522 2837 dbSNP
rs1363835363 2839 dbSNP
rs951470301 2840 dbSNP
rs755456196 2841 dbSNP
rs1457763435 2854 dbSNP
rs34237673 2856 dbSNP
rs1162025391 2873 dbSNP
rs527277305 2875 dbSNP
rs1199859990 2880 dbSNP
rs1481261543 2881 dbSNP
rs868173144 2886 dbSNP
rs1204439345 2888 dbSNP
rs35778959 2890 dbSNP
rs1420865101 2897 dbSNP
rs984112676 2900 dbSNP
rs909922538 2901 dbSNP
rs1397252822 2902 dbSNP
rs142185959 2905 dbSNP
rs1225754686 2908 dbSNP
rs765689401 2909 dbSNP
rs1339476189 2925 dbSNP
rs2285547 2926 dbSNP
rs545944674 2937 dbSNP
rs933184692 2941 dbSNP
rs1052055529 2943 dbSNP
rs562948094 2944 dbSNP
rs1404913719 2946 dbSNP
rs866380281 2948 dbSNP
rs1215824287 2951 dbSNP
rs1258879937 2954 dbSNP
rs923272775 2961 dbSNP
rs1429018943 2965 dbSNP
rs1264030985 2967 dbSNP
rs1202215762 2975 dbSNP
rs1460884988 2976 dbSNP
rs780972281 2979 dbSNP
rs531970431 2980 dbSNP
rs1423481777 2982 dbSNP
rs542153415 2982 dbSNP
rs1181932472 2994 dbSNP
rs1251073060 2997 dbSNP
rs1228872959 3002 dbSNP
rs935118677 3003 dbSNP
rs1311130784 3010 dbSNP
rs368146627 3012 dbSNP
rs933418706 3012 dbSNP
rs150791567 3017 dbSNP
rs114946552 3018 dbSNP
rs1470738831 3019 dbSNP
rs1012419439 3026 dbSNP
rs547433271 3027 dbSNP
rs941894995 3029 dbSNP
rs1462486563 3030 dbSNP
rs763813214 3038 dbSNP
rs906671675 3039 dbSNP
rs1003697834 3042 dbSNP
rs755829987 3046 dbSNP
rs1185717334 3066 dbSNP
rs1456604753 3070 dbSNP
rs1037517699 3071 dbSNP
rs897719528 3075 dbSNP
rs1341822278 3077 dbSNP
rs570423757 3080 dbSNP
rs1005641829 3090 dbSNP
rs906228469 3091 dbSNP
rs1358166865 3094 dbSNP
rs539319608 3127 dbSNP
rs1400826242 3134 dbSNP
rs1016911065 3140 dbSNP
rs1454308964 3141 dbSNP
rs555968837 3144 dbSNP
rs1001951294 3146 dbSNP
rs975040407 3150 dbSNP
rs533064758 3151 dbSNP
rs749055960 3152 dbSNP
rs921852412 3153 dbSNP
rs867551330 3159 dbSNP
rs1165530311 3162 dbSNP
rs1437840836 3165 dbSNP
rs768597627 3166 dbSNP
rs1363440362 3175 dbSNP
rs954815139 3179 dbSNP
rs987315713 3181 dbSNP
rs1182750394 3185 dbSNP
rs1239152875 3189 dbSNP
rs1439941397 3190 dbSNP
rs774195576 3194 dbSNP
rs1313858518 3195 dbSNP
rs1291946374 3201 dbSNP
rs1210665304 3203 dbSNP
rs935045167 3211 dbSNP
rs1347842902 3212 dbSNP
rs1278625575 3216 dbSNP
rs181522565 3223 dbSNP
rs923290434 3231 dbSNP
rs1301035198 3248 dbSNP
rs1404315190 3251 dbSNP
rs954904161 3255 dbSNP
rs115497413 3256 dbSNP
rs1417969894 3260 dbSNP
rs1278205943 3262 dbSNP
rs947765248 3264 dbSNP
rs6005034 3265 dbSNP
rs1376352130 3269 dbSNP
rs906775307 3269 dbSNP
rs772199225 3270 dbSNP
rs543745259 3273 dbSNP
rs555357762 3273 dbSNP
rs1215038712 3274 dbSNP
rs113886812 3278 dbSNP
rs189775686 3282 dbSNP
rs1205401854 3284 dbSNP
rs773493136 3285 dbSNP
rs887280659 3300 dbSNP
rs929221431 3301 dbSNP
rs1046777711 3302 dbSNP
rs1222674624 3303 dbSNP
rs906183347 3307 dbSNP
rs180742984 3312 dbSNP
rs1017046453 3322 dbSNP
rs1325970028 3332 dbSNP
rs576884167 3343 dbSNP
rs893530993 3346 dbSNP
rs1404203523 3354 dbSNP
rs1175888626 3359 dbSNP
rs1470526137 3360 dbSNP
rs1431844348 3374 dbSNP
rs996843507 3378 dbSNP
rs1475358334 3383 dbSNP
rs1030112230 3389 dbSNP
rs1021761815 3393 dbSNP
rs903387625 3396 dbSNP
rs1260895892 3397 dbSNP
rs545881154 3398 dbSNP
rs556662389 3400 dbSNP
rs139209821 3403 dbSNP
rs955004470 3408 dbSNP
rs1361168815 3410 dbSNP
rs1030760925 3411 dbSNP
rs542447269 3414 dbSNP
rs1017569370 3421 dbSNP
rs1219743632 3422 dbSNP
rs1300429021 3425 dbSNP
rs989167022 3426 dbSNP
rs963393311 3431 dbSNP
rs1168755213 3433 dbSNP
rs766601466 3434 dbSNP
rs186271915 3440 dbSNP
rs528016223 3442 dbSNP
rs1450831100 3445 dbSNP
rs540981754 3452 dbSNP
rs939584755 3455 dbSNP
rs1043260 3459 dbSNP
rs1043264 3460 dbSNP
rs564082425 3463 dbSNP
rs1204047593 3464 dbSNP
rs1047357546 3467 dbSNP
rs1306646872 3470 dbSNP
rs11913346 3471 dbSNP
rs941489380 3483 dbSNP
rs535615292 3485 dbSNP
rs15127 3489 dbSNP
rs1268792730 3492 dbSNP
rs549608491 3494 dbSNP
rs555824996 3503 dbSNP
rs903333814 3506 dbSNP
rs148867912 3510 dbSNP
rs532791034 3510 dbSNP
rs569765648 3519 dbSNP
rs1030515198 3520 dbSNP
rs1355441807 3530 dbSNP
rs899904867 3539 dbSNP
rs997380699 3548 dbSNP
rs1172162824 3549 dbSNP
rs1423660097 3550 dbSNP
rs529045735 3559 dbSNP
rs1162372272 3567 dbSNP
rs1444642332 3574 dbSNP
rs1364657368 3578 dbSNP
rs1175067098 3580 dbSNP
rs1216757776 3580 dbSNP
rs1281626567 3580 dbSNP
rs1361867100 3580 dbSNP
rs137932565 3580 dbSNP
rs143569858 3580 dbSNP
rs369529613 3580 dbSNP
rs537439856 3580 dbSNP
rs548687400 3580 dbSNP
rs55778752 3580 dbSNP
rs747542713 3580 dbSNP
rs201239212 3583 dbSNP
rs1403710894 3590 dbSNP
rs891128848 3592 dbSNP
rs1365512594 3593 dbSNP
rs1167793936 3600 dbSNP
rs1008786615 3604 dbSNP
rs1351074247 3606 dbSNP
rs754346698 3606 dbSNP
rs781516829 3606 dbSNP
rs1156541042 3609 dbSNP
rs751109383 3613 dbSNP
rs1418125564 3614 dbSNP
rs1436911309 3615 dbSNP
rs58683340 3616 dbSNP
rs1408509774 3619 dbSNP
rs1292912045 3632 dbSNP
rs549180573 3639 dbSNP
rs1184070740 3643 dbSNP
rs3182906 3646 dbSNP
rs1479293041 3651 dbSNP
rs1268128158 3652 dbSNP
rs1223089662 3662 dbSNP
rs1489531358 3669 dbSNP
rs1343545638 3684 dbSNP
rs1007813459 3689 dbSNP
rs866595624 3696 dbSNP
rs956647113 3697 dbSNP
rs1215410213 3704 dbSNP
rs1317740708 3710 dbSNP
rs1280212930 3729 dbSNP
rs1222082314 3742 dbSNP
rs989261930 3746 dbSNP
rs1341141361 3747 dbSNP
rs1214220610 3756 dbSNP
rs1284519065 3762 dbSNP
rs1017558135 3763 dbSNP
rs1022119690 3768 dbSNP
rs1271131577 3770 dbSNP
rs1369164794 3780 dbSNP
rs969124244 3784 dbSNP
rs192129544 3786 dbSNP
rs927620862 3790 dbSNP
rs963378876 3802 dbSNP
rs960670712 3804 dbSNP
rs534611174 3808 dbSNP
rs982467327 3809 dbSNP
rs1200123196 3811 dbSNP
rs1434824973 3812 dbSNP
rs1026377557 3813 dbSNP
rs908780852 3815 dbSNP
rs1486202191 3816 dbSNP
rs1243669350 3819 dbSNP
rs372806940 3823 dbSNP
rs1201963714 3828 dbSNP
rs1323323655 3833 dbSNP
rs1264117480 3840 dbSNP
rs1474319586 3849 dbSNP
rs950846759 3854 dbSNP
rs759853972 3856 dbSNP
rs1295406237 3860 dbSNP
rs941626791 3862 dbSNP
rs765746358 3863 dbSNP
rs982323349 3875 dbSNP
rs1185662846 3879 dbSNP
rs927827080 3883 dbSNP
rs1038546663 3890 dbSNP
rs1467330161 3891 dbSNP
rs570506825 3899 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 1399.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
IDDuplex structurePosition
1
miRNA  3' guguuuGGUAAUACACGACGAu 5'
                |::||   ||||||| 
Target 5' ----ccCUGUUUCCUGCUGCUu 3'
1 - 18
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions CMK , HEL , K-562 , Kasumi-1 , KG-1 , M-07e , ME-1 , MONO-MAC-1 MV4-11 , NB-4 , OCI-AML2 , OCI-AML5 , THP-1 , UT-7 HeLa
Disease acute myeloid leukemia
Location of target site 3'UTR
Tools used in this research MicroCosm , miRBase Target Database , PicTar , TargetScan
Original Description (Extracted from the article) ... NPM1 mutant associated miRNAs target and regulate a large number of NPM1 mutant associated genes with known or potential implication in leukemogenesis ...

- Russ AC; Sander S; Luck SC; Lang KM; Bauer et al., 2011, Haematologica.

Article - Russ AC; Sander S; Luck SC; Lang KM; Bauer et al.
- Haematologica, 2011
BACKGROUND: MicroRNAs are regulators of gene expression, which act mainly by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been shown for acute myeloid leukemia, a disease also characterized by altered gene expression associated with distinct genomic aberrations such as nucleophosmin (NPM1) mutations. To shed further light on the role of deregulated microRNA and gene expression in cytogenetically normal acute myeloid leukemia with NPM1 mutation we performed an integrative analysis of microRNA and mRNA expression data sets. DESIGN AND METHODS: Both microRNA and gene expression profiles were investigated in samples from a cohort of adult cytogenetically normal acute myeloid leukemia patients (n=43; median age 46 years, range 23-60 years) with known NPM1 mutation status (n=23 mutated, n=20 wild-type) and the data were integratively analyzed. Putative microRNA-mRNA interactions were validated by quantitative reverse transcriptase polymerase chain reaction, western blotting and luciferase reporter assays. For selected microRNAs, sensitivity of microRNA-overexpressing cells to cytarabine treatment was tested by FACS viability and cell proliferation assays. RESULTS: Our integrative approach of analyzing both microRNA- and gene expression profiles in parallel resulted in a refined list of putative target genes affected by NPM1 mutation-associated microRNA deregulation. Of 177 putative microRNA - target mRNA interactions we identified and validated 77 novel candidates with known or potential involvement in leukemogenesis, such as IRF2-miR-20a, KIT-miR-20a and MN1-miR-15a. Furthermore, our data showed that deregulated expression of tumor suppressor microRNAs, such as miR-29a and miR-30c, might contribute to sensitivity to cytarabine, which is observed in NPM1 mutated acute myeloid leukemia. CONCLUSIONS: Overall, our observations highlight that integrative data analysis approaches can improve insights into leukemia biology, and lead to the identification of novel microRNA - target gene interactions of potential relevance for acute myeloid leukemia treatment.
LinkOut: [PMID: 21880628]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000354336.3 | 3UTR | CCCUGUUUCCUGCUGCUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.528 8.4e-3 0.612 2.1e-3 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.462 1.0e-2 0.550 2.2e-3 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.445 1.7e-2 -0.313 7.3e-2 23 Click to see details
GSE14794 Lymphoblastoid cells 0.144 8.8e-2 0.139 9.6e-2 90 Click to see details
GSE19783 ER- ER- breast cancer 0.135 1.2e-1 0.083 2.3e-1 79 Click to see details
GSE21032 Prostate cancer 0.121 1.4e-1 0.105 1.7e-1 83 Click to see details
GSE21849 B cell lymphoma 0.194 1.6e-1 0.491 3.4e-3 29 Click to see details
GSE38226 Liver fibrosis 0.198 1.9e-1 0.209 1.8e-1 21 Click to see details
GSE28544 Breast cancer -0.18 2.0e-1 -0.515 5.0e-3 24 Click to see details
GSE19536 Breast cancer 0.083 2.1e-1 0.045 3.3e-1 100 Click to see details
GSE19783 ER+ ER+ breast cancer -0.17 2.4e-1 -0.152 2.6e-1 20 Click to see details
GSE27834 Pluripotent stem cells 0.184 2.5e-1 0.115 3.4e-1 16 Click to see details
GSE17498 Multiple myeloma 0.107 2.6e-1 0.188 1.2e-1 40 Click to see details
GSE19350 CNS germ cell tumors 0.191 2.8e-1 0.126 3.5e-1 12 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.121 2.8e-1 0.179 2.0e-1 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.098 3.2e-1 0.129 2.7e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.021 4.5e-1 0.045 4.0e-1 32 Click to see details
GSE17306 Multiple myeloma 0.014 4.6e-1 -0.057 3.5e-1 49 Click to see details
GSE28260 Renal cortex and medulla -0.018 4.8e-1 -0.049 4.4e-1 13 Click to see details
GSE21687 Ependynoma primary tumors -0.003 4.9e-1 0.017 4.5e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.003 4.9e-1 0.017 4.5e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PAAD 0.989 0.01 0.800 0.1 4 Click to see details
PCPG 0.999 0.01 1.000 0.5 3 Click to see details
STAD -0.212 0.12 -0.343 0.03 32 Click to see details
LUAD 0.314 0.16 0.462 0.07 12 Click to see details
HNSC 0.146 0.18 0.161 0.15 42 Click to see details
KICH -0.18 0.19 -0.169 0.21 25 Click to see details
CHOL -0.325 0.2 0.033 0.47 9 Click to see details
BLCA 0.175 0.24 0.441 0.03 18 Click to see details
BRCA -0.076 0.25 -0.133 0.11 84 Click to see details
ESCA -0.22 0.26 -0.327 0.16 11 Click to see details
LIHC 0.079 0.29 0.064 0.33 49 Click to see details
CESC 0.59 0.3 0.500 0.33 3 Click to see details
KIRP -0.085 0.32 -0.059 0.37 32 Click to see details
KIRC -0.031 0.4 -0.097 0.22 68 Click to see details
LUSC 0.04 0.41 0.038 0.41 38 Click to see details
COAD 0.088 0.42 0.143 0.37 8 Click to see details
PRAD -0.023 0.44 0.032 0.41 50 Click to see details
UCEC -0.013 0.48 -0.139 0.29 19 Click to see details
THCA -0.006 0.48 0.000 0.5 59 Click to see details
THCA -0.006 0.48 0.000 0.5 59 Click to see details
THCA -0.006 0.48 0.000 0.5 59 Click to see details
MiRNA Regulatory Network:
Functional analysis:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR) Other evidence
Transcription factor regulation Circular RNA sponge
694 hsa-miR-15a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000280 BMI1 BMI1 proto-oncogene, polycomb ring finger 5 3
MIRT000282 WNT3A Wnt family member 3A 3 2
MIRT000283 MYB MYB proto-oncogene, transcription factor 5 3
MIRT000284 CDC25A cell division cycle 25A 4 4
MIRT000285 CCND2 cyclin D2 4 7
MIRT000804 RAB9B RAB9B, member RAS oncogene family 1 1
MIRT000806 ACTR1A ARP1 actin related protein 1 homolog A 1 1
MIRT000808 TPI1 triosephosphate isomerase 1 1 1
MIRT000810 PDCD4 programmed cell death 4 3 2
MIRT000812 RAB21 RAB21, member RAS oncogene family 2 1
MIRT000815 BCL2 BCL2, apoptosis regulator 6 13
MIRT000817 WT1 Wilms tumor 1 2 1
MIRT000819 ASXL2 additional sex combs like 2, transcriptional regulator 2 1
MIRT000823 TMEM251 transmembrane protein 251 2 1
MIRT000825 CARD8 caspase recruitment domain family member 8 2 1
MIRT000827 CDC14B cell division cycle 14B 2 1
MIRT000829 CENPJ centromere protein J 2 1
MIRT000831 CEP63 centrosomal protein 63 2 1
MIRT000833 CREBL2 cAMP responsive element binding protein like 2 4 5
MIRT000835 ECHDC1 ethylmalonyl-CoA decarboxylase 1 2 1
MIRT000847 GOLGA5 golgin A5 2 1
MIRT000849 GOLPH3L golgi phosphoprotein 3 like 2 1
MIRT000851 GTF2H1 general transcription factor IIH subunit 1 2 1
MIRT000853 H3F3B H3 histone family member 3B 2 1
MIRT000855 HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 2 1
MIRT000857 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 1
MIRT000859 HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2 1
MIRT000863 HRSP12 reactive intermediate imine deaminase A homolog 2 1
MIRT000865 HSDL2 hydroxysteroid dehydrogenase like 2 2 1
MIRT000866 HSPA1A heat shock protein family A (Hsp70) member 1A 2 1
MIRT000868 JUN Jun proto-oncogene, AP-1 transcription factor subunit 2 1
MIRT000878 MCL1 MCL1, BCL2 family apoptosis regulator 2 1
MIRT000880 MSH2 mutS homolog 2 2 1
MIRT000884 OMA1 OMA1 zinc metallopeptidase 2 1
MIRT000886 OSGEPL1 O-sialoglycoprotein endopeptidase like 1 2 1
MIRT000888 PDCD6IP programmed cell death 6 interacting protein 2 1
MIRT000890 PHKB phosphorylase kinase regulatory subunit beta 2 1
MIRT000892 PMS1 PMS1 homolog 1, mismatch repair system component 2 1
MIRT000894 PNN pinin, desmosome associated protein 2 1
MIRT000896 PRIM1 DNA primase subunit 1 2 1
MIRT000898 RAD51C RAD51 paralog C 2 1
MIRT000900 RHOT1 ras homolog family member T1 2 1
MIRT000902 RNASEL ribonuclease L 2 1
MIRT000906 SLC35A1 solute carrier family 35 member A1 2 1
MIRT000908 SLC35B3 solute carrier family 35 member B3 2 1
MIRT000910 TIA1 TIA1 cytotoxic granule associated RNA binding protein 2 1
MIRT000914 UGDH UDP-glucose 6-dehydrogenase 2 1
MIRT000916 UGP2 UDP-glucose pyrophosphorylase 2 2 1
MIRT000922 ZNF559 zinc finger protein 559 2 1
MIRT001227 CCND1 cyclin D1 6 8
MIRT001228 CCNE1 cyclin E1 7 10
MIRT001802 BACE1 beta-secretase 1 2 1
MIRT002946 DMTF1 cyclin D binding myb like transcription factor 1 4 4
MIRT003330 RPS6 ribosomal protein S6 0 1
MIRT003333 BRCA1 BRCA1, DNA repair associated 2 2
MIRT003334 AKT3 AKT serine/threonine kinase 3 3 6
MIRT003872 WIPF1 WAS/WASL interacting protein family member 1 2 1
MIRT003873 VPS45 vacuolar protein sorting 45 homolog 2 1
MIRT003874 HSP90B1 heat shock protein 90 beta family member 1 2 1
MIRT003875 SKAP2 src kinase associated phosphoprotein 2 3 1
MIRT003876 NT5DC1 5'-nucleotidase domain containing 1 2 1
MIRT003877 FAM69A family with sequence similarity 69 member A 2 1
MIRT003878 C2orf74 chromosome 2 open reading frame 74 1 1
MIRT003879 FAM122C family with sequence similarity 122C 2 1
MIRT003880 PWWP2A PWWP domain containing 2A 2 1
MIRT003881 C17orf80 chromosome 17 open reading frame 80 2 1
MIRT003882 CCDC111 primase and DNA directed polymerase 2 1
MIRT003883 C2orf43 lipid droplet associated hydrolase 2 1
MIRT003884 C4orf27 histone PARylation factor 1 2 1
MIRT003885 NIPAL2 NIPA like domain containing 2 2 1
MIRT003886 TRMT13 tRNA methyltransferase 13 homolog 2 1
MIRT003887 ANAPC16 anaphase promoting complex subunit 16 2 1
MIRT003888 CADM1 cell adhesion molecule 1 3 1
MIRT003891 TMEM184B transmembrane protein 184B 2 1
MIRT003899 APP amyloid beta precursor protein 4 3
MIRT004046 UCP2 uncoupling protein 2 3 1
MIRT004275 VEGFA vascular endothelial growth factor A 7 17
MIRT004680 TSPYL2 TSPY like 2 2 1
MIRT004829 NFKB1 nuclear factor kappa B subunit 1 3 1
MIRT005552 CHUK conserved helix-loop-helix ubiquitous kinase 4 1
MIRT005763 TP53 tumor protein p53 1 1
MIRT006027 FGF7 fibroblast growth factor 7 2 1
MIRT006176 CLCN3 chloride voltage-gated channel 3 4 1
MIRT006177 CRKL CRK like proto-oncogene, adaptor protein 6 3
MIRT006181 MN1 MN1 proto-oncogene, transcriptional regulator 4 1
MIRT006658 Ccnd1 cyclin D1 2 2
MIRT006801 HMGA1 high mobility group AT-hook 1 4 2
MIRT006805 HMGA2 high mobility group AT-hook 2 3 1
MIRT006913 IFNG interferon gamma 2 1
MIRT006998 PURA purine rich element binding protein A 2 2
MIRT007090 RECK reversion inducing cysteine rich protein with kazal motifs 4 3
MIRT032077 DLK1 delta like non-canonical Notch ligand 1 2 1
MIRT051311 PLA2G2D phospholipase A2 group IID 1 1
MIRT051312 ACVR1B activin A receptor type 1B 1 1
MIRT051313 IKBKG inhibitor of nuclear factor kappa B kinase subunit gamma 1 1
MIRT051314 GCLM glutamate-cysteine ligase modifier subunit 1 1
MIRT051315 PCF11 PCF11 cleavage and polyadenylation factor subunit 1 1
MIRT051316 HIST1H2BK histone cluster 1 H2B family member k 1 1
MIRT051317 ODC1 ornithine decarboxylase 1 1 1
MIRT051318 CALD1 caldesmon 1 1 1
MIRT051319 RPP30 ribonuclease P/MRP subunit p30 1 1
MIRT051320 ASNSD1 asparagine synthetase domain containing 1 1 1
MIRT051321 CCNYL1 cyclin Y like 1 1 1
MIRT051322 RGPD5 RANBP2-like and GRIP domain containing 5 1 1
MIRT051323 PREB prolactin regulatory element binding 1 1
MIRT051324 PDHX pyruvate dehydrogenase complex component X 1 1
MIRT051325 SNX6 sorting nexin 6 1 1
MIRT051326 CNN3 calponin 3 1 1
MIRT051327 KIF1A kinesin family member 1A 1 1
MIRT051328 NAB1 NGFI-A binding protein 1 1 1
MIRT051329 CCT6B chaperonin containing TCP1 subunit 6B 1 1
MIRT051330 CHD4 chromodomain helicase DNA binding protein 4 1 1
MIRT051331 CLCC1 chloride channel CLIC like 1 1 1
MIRT051332 GDI2 GDP dissociation inhibitor 2 1 1
MIRT051333 BRWD1 bromodomain and WD repeat domain containing 1 1 1
MIRT051334 MAPK6 mitogen-activated protein kinase 6 1 1
MIRT051335 PSMC4 proteasome 26S subunit, ATPase 4 1 1
MIRT051336 ATF2 activating transcription factor 2 1 1
MIRT051337 ATP6AP1 ATPase H+ transporting accessory protein 1 1 1
MIRT051338 FBXO3 F-box protein 3 1 1
MIRT051339 PRDX3 peroxiredoxin 3 1 1
MIRT051340 CABIN1 calcineurin binding protein 1 1 1
MIRT051341 FASN fatty acid synthase 2 5
MIRT051342 SEC63 SEC63 homolog, protein translocation regulator 1 1
MIRT051343 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 1 1
MIRT051344 DSTYK dual serine/threonine and tyrosine protein kinase 1 1
MIRT051345 FOXO1 forkhead box O1 4 2
MIRT051346 TMEM214 transmembrane protein 214 1 1
MIRT051347 TRIM28 tripartite motif containing 28 1 1
MIRT051348 NOP2 NOP2 nucleolar protein 1 1
MIRT051349 MYBL1 MYB proto-oncogene like 1 1 1
MIRT051350 TTC1 tetratricopeptide repeat domain 1 1 1
MIRT051351 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 1 2
MIRT052930 REPIN1 replication initiator 1 2 1
MIRT053079 KLF4 Kruppel like factor 4 2 1
MIRT054283 YAP1 Yes associated protein 1 3 1
MIRT054424 CARM1 coactivator associated arginine methyltransferase 1 3 1
MIRT054895 SOX5 SRY-box 5 2 1
MIRT055421 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 11
MIRT055811 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT057514 CEP55 centrosomal protein 55 2 8
MIRT057729 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT057906 STXBP3 syntaxin binding protein 3 1 1
MIRT061005 C1ORF21 chromosome 1 open reading frame 21 2 6
MIRT061244 AMOTL1 angiomotin like 1 2 12
MIRT061529 BTG2 BTG anti-proliferation factor 2 1 1
MIRT063394 ETNK1 ethanolamine kinase 1 1 1
MIRT065711 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 4
MIRT066291 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT066312 USP15 ubiquitin specific peptidase 15 2 2
MIRT068655 AKAP11 A-kinase anchoring protein 11 1 1
MIRT071206 FCF1 FCF1, rRNA-processing protein 2 2
MIRT072822 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 5
MIRT074530 PAGR1 PAXIP1 associated glutamate rich protein 1 2 4
MIRT075249 SNTB2 syntrophin beta 2 2 4
MIRT075273 VPS4A vacuolar protein sorting 4 homolog A 2 8
MIRT075891 C16ORF72 chromosome 16 open reading frame 72 2 7
MIRT076791 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT077781 MINK1 misshapen like kinase 1 1 1
MIRT078282 RPS6KB1 ribosomal protein S6 kinase B1 2 2
MIRT079655 NAPG NSF attachment protein gamma 2 12
MIRT080011 GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 2 4
MIRT082985 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT083265 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT084462 SOWAHC sosondowah ankyrin repeat domain family member C 2 4
MIRT085215 CCNT2 cyclin T2 1 1
MIRT086005 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087424 ZNRF3 zinc and ring finger 3 2 2
MIRT087554 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 2
MIRT088102 SEPT2 septin 2 1 1
MIRT089105 B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2 4
MIRT089206 ACTR2 ARP2 actin related protein 2 homolog 2 3
MIRT090446 CDV3 CDV3 homolog 1 1
MIRT090688 U2SURP U2 snRNP associated SURP domain containing 1 1
MIRT091667 RARB retinoic acid receptor beta 2 6
MIRT092190 ITPR1 inositol 1,4,5-trisphosphate receptor type 1 1 1
MIRT092209 BHLHE40 basic helix-loop-helix family member e40 1 1
MIRT093682 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT096234 CANX calnexin 2 2
MIRT098827 PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 1
MIRT099631 E2F3 E2F transcription factor 3 1 1
MIRT100207 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT100364 HSPA1B heat shock protein family A (Hsp70) member 1B 3 8
MIRT100566 PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2 2
MIRT100896 CD2AP CD2 associated protein 2 2
MIRT102434 CALU calumenin 2 3
MIRT102632 UBN2 ubinuclein 2 2 11
MIRT102971 EN2 engrailed homeobox 2 2 6
MIRT103092 MAFK MAF bZIP transcription factor K 2 5
MIRT103856 FOXK1 forkhead box K1 2 3
MIRT104015 USP42 ubiquitin specific peptidase 42 2 6
MIRT106292 ZFHX4 zinc finger homeobox 4 2 6
MIRT106733 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 3
MIRT107218 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT108983 SLC9A6 solute carrier family 9 member A6 1 1
MIRT109240 ZNF275 zinc finger protein 275 2 2
MIRT110051 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 7
MIRT112969 LUZP1 leucine zipper protein 1 2 6
MIRT114923 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT117655 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT120680 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT127725 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 3
MIRT128798 UBE4A ubiquitination factor E4A 1 1
MIRT129055 ARCN1 archain 1 1 1
MIRT130380 PTPRJ protein tyrosine phosphatase, receptor type J 1 1
MIRT131097 TMEM138 transmembrane protein 138 1 1
MIRT132734 RASSF5 Ras association domain family member 5 1 1
MIRT132831 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1 1
MIRT133334 BCL7A BCL tumor suppressor 7A 1 1
MIRT133769 SKI SKI proto-oncogene 2 3
MIRT137517 RCOR1 REST corepressor 1 1 1
MIRT140146 SPRED1 sprouty related EVH1 domain containing 1 2 3
MIRT140820 SMAD3 SMAD family member 3 1 1
MIRT141243 SCAMP5 secretory carrier membrane protein 5 1 1
MIRT141279 UBE2Q2 ubiquitin conjugating enzyme E2 Q2 1 1
MIRT142237 DCTN5 dynactin subunit 5 2 9
MIRT144019 PSKH1 protein serine kinase H1 1 1
MIRT145377 ANKRD13B ankyrin repeat domain 13B 1 1
MIRT146014 EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 1 1
MIRT146351 PNPO pyridoxamine 5'-phosphate oxidase 1 1
MIRT146496 SNX11 sorting nexin 11 1 1
MIRT148302 RNF138 ring finger protein 138 1 1
MIRT150354 IER2 immediate early response 2 1 1
MIRT152274 TNFSF9 TNF superfamily member 9 2 3
MIRT152503 ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 1 1
MIRT152736 KIF3B kinesin family member 3B 1 1
MIRT152922 NOL4L nucleolar protein 4 like 2 3
MIRT154043 RASSF2 Ras association domain family member 2 2 2
MIRT154392 CDS2 CDP-diacylglycerol synthase 2 1 1
MIRT156452 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT158519 TNRC6B trinucleotide repeat containing 6B 2 5
MIRT158990 EPT1 selenoprotein I 1 1
MIRT159580 PEX13 peroxisomal biogenesis factor 13 1 1
MIRT160169 TET3 tet methylcytosine dioxygenase 3 1 1
MIRT163253 PRKCD protein kinase C delta 1 1
MIRT164260 CPEB2 cytoplasmic polyadenylation element binding protein 2 1 1
MIRT164952 TADA2B transcriptional adaptor 2B 1 1
MIRT165172 GRAMD3 GRAM domain containing 2B 2 3
MIRT165883 CREBRF CREB3 regulatory factor 2 3
MIRT168680 CDKN1A cyclin dependent kinase inhibitor 1A 1 1
MIRT169058 IRF4 interferon regulatory factor 4 1 1
MIRT170136 KLHDC10 kelch domain containing 10 1 1
MIRT170733 UBE3C ubiquitin protein ligase E3C 1 1
MIRT171597 SUN1 Sad1 and UNC84 domain containing 1 1 1
MIRT172813 HMBOX1 homeobox containing 1 1 1
MIRT174781 RNF38 ring finger protein 38 1 1
MIRT175232 PSAT1 phosphoserine aminotransferase 1 2 7
MIRT175524 ZBTB33 zinc finger and BTB domain containing 33 1 1
MIRT179008 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT180909 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 8
MIRT186371 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT189760 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT189961 AGO4 argonaute 4, RISC catalytic component 2 2
MIRT190184 GPR180 G protein-coupled receptor 180 2 6
MIRT191454 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT191625 SLC39A9 solute carrier family 39 member 9 2 6
MIRT194237 FAM103A1 family with sequence similarity 103 member A1 2 6
MIRT194903 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT196275 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 1 1
MIRT196450 TAOK1 TAO kinase 1 2 2
MIRT201456 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT204592 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204623 MOB4 MOB family member 4, phocein 2 8
MIRT204741 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT206020 NUP50 nucleoporin 50 2 7
MIRT211199 FGF2 fibroblast growth factor 2 2 4
MIRT211314 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 4
MIRT212604 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 8
MIRT217743 TBPL1 TATA-box binding protein like 1 2 3
MIRT223681 FZD6 frizzled class receptor 6 2 6
MIRT224965 BAG4 BCL2 associated athanogene 4 2 2
MIRT229343 ZNF449 zinc finger protein 449 2 2
MIRT229860 YIPF6 Yip1 domain family member 6 2 2
MIRT230120 DDX3Y DEAD-box helicase 3, Y-linked 1 1
MIRT234342 MSL1 male specific lethal 1 homolog 2 8
MIRT245003 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 1 1
MIRT246938 PRRC2C proline rich coiled-coil 2C 1 1
MIRT247095 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT247236 ELK4 ELK4, ETS transcription factor 2 4
MIRT247368 GABARAPL1 GABA type A receptor associated protein like 1 2 6
MIRT248550 PDIK1L PDLIM1 interacting kinase 1 like 1 1
MIRT248765 ATXN7L3B ataxin 7 like 3B 2 4
MIRT249449 ZNF691 zinc finger protein 691 2 4
MIRT251487 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT255333 SRPRB SRP receptor beta subunit 2 5
MIRT256305 CDC42SE2 CDC42 small effector 2 2 2
MIRT258410 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 3
MIRT265056 TBRG1 transforming growth factor beta regulator 1 2 2
MIRT265076 CHEK1 checkpoint kinase 1 2 3
MIRT267254 TMEM109 transmembrane protein 109 1 1
MIRT267527 C1ORF226 chromosome 1 open reading frame 226 2 2
MIRT270454 SIRT4 sirtuin 4 1 1
MIRT270552 SETD1B SET domain containing 1B 2 2
MIRT273665 HOXC8 homeobox C8 2 2
MIRT274741 RAB3IP RAB3A interacting protein 2 2
MIRT277504 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT282532 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT286968 MLLT6 MLLT6, PHD finger containing 1 1
MIRT289625 CBX2 chromobox 2 2 2
MIRT294283 ZFP28 ZFP28 zinc finger protein 2 2
MIRT295810 CHMP4B charged multivesicular body protein 4B 2 2
MIRT297778 GABPA GA binding protein transcription factor alpha subunit 2 4
MIRT300100 STRADB STE20-related kinase adaptor beta 2 2
MIRT300992 MTMR3 myotubularin related protein 3 2 2
MIRT302611 CRIM1 cysteine rich transmembrane BMP regulator 1 2 6
MIRT302825 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT307141 CTDSPL CTD small phosphatase like 2 4
MIRT313675 ITGA2 integrin subunit alpha 2 2 2
MIRT314051 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT317722 PPIL1 peptidylprolyl isomerase like 1 2 7
MIRT319331 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT320626 ZNRF2 zinc and ring finger 2 2 2
MIRT324839 IFT74 intraflagellar transport 74 1 1
MIRT326301 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT327962 CHIC1 cysteine rich hydrophobic domain 1 2 6
MIRT437998 KLF6 Kruppel like factor 6 2 1
MIRT438163 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 3 1
MIRT438610 RET ret proto-oncogene 3 1
MIRT443809 SIDT2 SID1 transmembrane family member 2 2 2
MIRT446508 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT447778 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT448440 TLL1 tolloid like 1 2 2
MIRT449190 LUC7L3 LUC7 like 3 pre-mRNA splicing factor 2 2
MIRT451839 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT453288 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT453754 CSNK1E casein kinase 1 epsilon 2 2
MIRT454970 TPM2 tropomyosin 2 2 2
MIRT456867 ZNF460 zinc finger protein 460 2 10
MIRT460224 FGFR4 fibroblast growth factor receptor 4 2 2
MIRT460438 DOCK11 dedicator of cytokinesis 11 2 2
MIRT461564 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463167 ZNF367 zinc finger protein 367 2 10
MIRT464668 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT464751 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 3
MIRT465165 TSC22D2 TSC22 domain family member 2 2 2
MIRT465570 TOB2 transducer of ERBB2, 2 2 2
MIRT465926 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT466008 TMEM189 transmembrane protein 189 2 8
MIRT466298 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT466436 TFAP2A transcription factor AP-2 alpha 2 8
MIRT466917 STK38 serine/threonine kinase 38 2 10
MIRT467002 SSRP1 structure specific recognition protein 1 2 5
MIRT468052 SIK1 salt inducible kinase 1 2 3
MIRT468151 SH3BP4 SH3 domain binding protein 4 2 2
MIRT468676 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT469090 RNF168 ring finger protein 168 2 2
MIRT469415 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471038 PISD phosphatidylserine decarboxylase 2 10
MIRT471495 PDE4D phosphodiesterase 4D 2 4
MIRT471956 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472263 NFIC nuclear factor I C 2 2
MIRT472665 NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 2 4
MIRT474318 LAMC1 laminin subunit gamma 1 2 2
MIRT474828 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT475068 IVNS1ABP influenza virus NS1A binding protein 2 6
MIRT475123 IPPK inositol-pentakisphosphate 2-kinase 2 2
MIRT475539 HOXA3 homeobox A3 2 8
MIRT475720 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT475843 HDGF heparin binding growth factor 2 4
MIRT476259 GNB1 G protein subunit beta 1 2 7
MIRT476276 GNAL G protein subunit alpha L 2 6
MIRT476698 FURIN furin, paired basic amino acid cleaving enzyme 2 2
MIRT477565 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 8
MIRT477849 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478911 CPSF7 cleavage and polyadenylation specific factor 7 2 6
MIRT479457 CDK6 cyclin dependent kinase 6 2 2
MIRT479988 CARD10 caspase recruitment domain family member 10 2 2
MIRT481181 AVL9 AVL9 cell migration associated 2 6
MIRT482370 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT482556 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 10
MIRT482581 ABHD2 abhydrolase domain containing 2 2 2
MIRT484778 ABCC6 ATP binding cassette subfamily C member 6 2 4
MIRT485215 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT487394 C10orf54 V-set immunoregulatory receptor 2 2
MIRT492715 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT494354 CASKIN1 CASK interacting protein 1 2 2
MIRT495146 ZNRF1 zinc and ring finger 1 2 2
MIRT496019 CD180 CD180 molecule 2 2
MIRT497776 KIAA0895 KIAA0895 2 2
MIRT498984 ORC4 origin recognition complex subunit 4 2 8
MIRT499456 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT499619 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 8
MIRT500097 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500321 ZNF622 zinc finger protein 622 2 9
MIRT500425 ZMAT3 zinc finger matrin-type 3 2 4
MIRT500580 USP53 ubiquitin specific peptidase 53 2 2
MIRT500860 SYPL1 synaptophysin like 1 2 8
MIRT500936 SRPR SRP receptor alpha subunit 2 7
MIRT500953 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501089 SMAD7 SMAD family member 7 2 8
MIRT501506 PRICKLE2 prickle planar cell polarity protein 2 2 2
MIRT502038 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT502151 KIF5B kinesin family member 5B 2 9
MIRT502496 FAM122B family with sequence similarity 122B 2 8
MIRT502570 E2F7 E2F transcription factor 7 2 11
MIRT502643 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502922 CDCA4 cell division cycle associated 4 4 9
MIRT502950 CDC37L1 cell division cycle 37 like 1 2 9
MIRT503140 ATG9A autophagy related 9A 2 7
MIRT504338 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504540 ZNF620 zinc finger protein 620 2 6
MIRT504855 HAUS3 HAUS augmin like complex subunit 3 2 6
MIRT505116 YTHDC1 YTH domain containing 1 2 6
MIRT505349 TMEM245 transmembrane protein 245 2 6
MIRT505398 TMEM100 transmembrane protein 100 2 2
MIRT505505 SRSF1 serine and arginine rich splicing factor 1 2 6
MIRT505549 SNX16 sorting nexin 16 2 6
MIRT505686 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT505911 RIMS3 regulating synaptic membrane exocytosis 3 2 6
MIRT505930 RCAN3 RCAN family member 3 2 4
MIRT506112 PPIG peptidylprolyl isomerase G 2 6
MIRT506138 PLRG1 pleiotropic regulator 1 2 4
MIRT506166 PLAG1 PLAG1 zinc finger 2 9
MIRT506194 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506487 MYO5A myosin VA 2 7
MIRT506854 KIF23 kinesin family member 23 2 7
MIRT507002 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 6
MIRT507820 CDK1 cyclin dependent kinase 1 2 6
MIRT507853 CCNE2 cyclin E2 2 6
MIRT507877 CBX6 chromobox 6 2 2
MIRT508041 AXIN2 axin 2 2 6
MIRT508644 CASK calcium/calmodulin dependent serine protein kinase 2 5
MIRT509368 DMPK DM1 protein kinase 2 11
MIRT509693 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT510047 AKR1B10 aldo-keto reductase family 1 member B10 2 4
MIRT511847 GPATCH8 G-patch domain containing 8 2 5
MIRT512288 ARHGDIA Rho GDP dissociation inhibitor alpha 2 7
MIRT512646 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 5
MIRT513854 JARID2 jumonji and AT-rich interaction domain containing 2 2 8
MIRT514020 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 5
MIRT514042 ATG14 autophagy related 14 2 2
MIRT518095 TRIM35 tripartite motif containing 35 2 2
MIRT518533 FLCN folliculin 2 6
MIRT518998 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT521055 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521207 SBNO1 strawberry notch homolog 1 2 6
MIRT521818 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT522098 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 5
MIRT522778 LAMP2 lysosomal associated membrane protein 2 2 6
MIRT537815 EFNB2 ephrin B2 2 4
MIRT539902 RPL14 ribosomal protein L14 2 4
MIRT540847 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541217 HOXA10 homeobox A10 2 2
MIRT541432 CBX4 chromobox 4 2 3
MIRT542810 PHC3 polyhomeotic homolog 3 2 3
MIRT542837 PDCD1 programmed cell death 1 2 7
MIRT543062 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT543310 ZNF585B zinc finger protein 585B 2 2
MIRT543411 ANAPC13 anaphase promoting complex subunit 13 2 2
MIRT543529 PRSS21 protease, serine 21 2 2
MIRT543801 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT543839 GSG1 germ cell associated 1 2 2
MIRT544575 POLDIP3 DNA polymerase delta interacting protein 3 2 2
MIRT544593 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT544916 CLSPN claspin 2 2
MIRT544969 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545190 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545351 CCDC83 coiled-coil domain containing 83 2 2
MIRT545686 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545961 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT545973 YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta 2 2
MIRT546118 USP48 ubiquitin specific peptidase 48 2 4
MIRT546611 SALL1 spalt like transcription factor 1 2 4
MIRT546619 RUNX1T1 RUNX1 translocation partner 1 2 2
MIRT546640 RTN4 reticulon 4 2 2
MIRT547069 PNISR PNN interacting serine and arginine rich protein 2 3
MIRT547131 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547233 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT547305 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 3
MIRT547406 MKX mohawk homeobox 2 2
MIRT547463 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 2
MIRT547546 LRRFIP2 LRR binding FLII interacting protein 2 2 4
MIRT547661 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547702 KPNA1 karyopherin subunit alpha 1 2 4
MIRT547968 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT548001 HCFC2 host cell factor C2 2 4
MIRT548018 GRB2 growth factor receptor bound protein 2 2 4
MIRT548219 FKBP1A FK506 binding protein 1A 2 2
MIRT548275 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT548727 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548809 CLIP4 CAP-Gly domain containing linker protein family member 4