miRNA - target interaction (MTI) corpus release

Corpus information:
	Manually curation of miRNA and target genes, and their relations in PubMed abstracts. 

Files:
	MTI-PubMed_corpus.txt : Sample Set (1006 articles) in txt format
	
Format:
	Tab-delimited txt file is for download in miRTarBase download page: http://mirtarbase.mbc.nctu.edu.tw/php/download.php
	The first row is title, and second row is abstract. The rows below abstract are bio-concept mentions. Between any two articles, a blank line is required. 
	We use four attributes to describe an annotation, separated by Tab keys. The four attributes are: 
			
		PMID<tab>annotation ID<tab>mention TYPE<tab>text MENTION
	
	Note:
	The second attribute "annotation ID" consists of two types, miRNA and Target_gene.
	The third attribute "mention TYPE" also contains START and END offset that separated by space keys.
		The START OFFSET is the first character offset of the mention while END OFFSET is the last. 
		
		
	Example:
		
		19937137	Title	miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2.
		19937137	Abstract	Previously, we have reported tissue- and stage-specific expression of miR-372 in human embryonic stem cells and so far, not many reports speculate the function of this microRNA (miRNA). In this study, we screened various human cancer cell lines including gastric cancer cell lines and found first time that miR-372 is expressed only in AGS human gastric adenocarcinoma cell line. Inhibition of miR-372 using antisense miR-372 oligonucleotide (AS-miR-372) suppressed proliferation, arrested the cell cycle at G2/M phase, and increased apoptosis of AGS cells. Furthermore, AS-miR-372 treatment increased expression of LATS2, while over-expression of miR-372 decreased luciferase reporter activity driven by the 3' untranslated region (3' UTR) of LATS2 mRNA. Over-expression of LATS2 induced changes in AGS cells similar to those in AGS cells treated with AS-miR-372. Taken together, these findings demonstrate an oncogenic role for miR-372 in controlling cell growth, cell cycle, and apoptosis through down-regulation of a tumor suppressor gene, LATS2. 
		19937137	T1	miRNA	miR-372
		19937137	T2	Target_gene	LATS2